Difference Between 70S and 80S Ribosomes

                    70S Ribosome

                  80S Ribosomes

They are majorly found in prokaryotic cells like bacteria and they are also found in a few eukaryotic cells. 

Majorly found in eukaryotic cells. 

They are found in free states inside the cytoplasm in prokaryotic cells, whereas in the case of eukaryotic cells they are found in few organelles like mitochondria and chloroplast. 

Mainly found in the cytoplasm or attached to the endoplasmic reticulum. 

Their synthesis mainly occurs inside the cytoplasm of prokaryotes. 

Their synthesis mainly occurs inside the nucleolus. 

Their smaller subunit is 30S and larger is 50S

Their smaller subunit is 40S and larger is 50s. 

They have 3 molecules of RNA.

They have 4 molecules of RNA. 

Their weight is approx 2.7-3.0 million Daltons.

Their weight is approx 4.0-4.5 million Daltons. 

Their sedimentation coefficient is 70. 

Their sedimentation coefficient is approx 80. 

There are about 55 protein molecules, with 34 in larger subunit and 21 in smaller subunit in 70s ribosomes. 

There are about 73 protein molecules, with 40 in larger subunits and 33 in smaller subunits. 

They have approx 8,000 amino acids. 

They have approx 16,000 amino acids. 

RNA-to-Protein ratio is 2:1. 

RNA-to-Protein ratio is 1:1. 

Antibiotics inhibit protein synthesis. 

Antibiotics do not inhibit protein synthesis.