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Difference Between Blood and Plasma

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Difference between Blood and Plasma - Introduction

Before discussing what is the difference between Blood and Plasma? Let us have some basic idea about Blood and Plasma. Then we can discuss in brief the Difference between Blood and Plasma. The same question can also be asked as “Difference between Blood and Blood Plasma”.

Know the Difference between Blood and Plasma

Before directly jumping into the topic let's first discuss what's the distinction between Blood and Plasma? So relax allows us to have some primary concept about Blood and Plasma Then we will talk in short about the distinction among Blood and Plasma. The same question also can be asked as “distinction among Blood and Blood Plasma”.

A Descriptive Difference between Blood and Plasma

  • Plasma is the liquid thing of Blood

  • Blood is the frame’s fluid connective tissue that constitutes 55% Plasma, 45% Blood Cells.


Blood is part of the circulatory system. It helps to carry oxygen, Nutrients, and metabolic wastes to different parts of the body in humans as well as animals and also helps to transport metabolic waste away from those same cells.

The main components of the Blood are Blood cells (RBC, WBC, and Platelets), suspended in the Blood Plasma. In Blood cells, RBCs (Red Blood Cells) are also known as erythrocytes and WBCs (White Blood cells) are also known as leukocytes. Platelets are also referred to as thrombocytes. Vertebrates generally have Blood that is red in colour due to the presence of haemoglobin. However, Blood is bright red in colour when haemoglobin is oxygenated and dark red in colour when Blood is deoxygenated.

Functions of Blood

Blood performs an important function; some of the functions are listed below.

  • It supplies oxygen and other important nutrients to the tissue.

  • It also helps to remove carbon dioxide and other waste products from the tissue.

  • It helps in clotting at the site of injury and is cut with the help of platelets.

  • It helps to regulate the temperature and Ph of the body.


Plasma is the major component of Blood. It acquires around 55% of the Blood and the rest 45% are RBC, WBC, and platelets. When only Plasma is separated from the Blood, it is light yellow in colour and it acquires Blood, salts, and enzymes. In simple words, we can say that the liquid part of Blood is known as Plasma.

The main function of Plasma is to carry nutrients, hormones, and proteins to the parts of the body that require them. It also includes antibodies, Clotting factors, proteins albumin, and fibrinogen. Plasma is donated to others to treat many serious health problems. If people want to donate Plasma, they go through a screening process to check Blood is healthy and safe.

Function of Plasma

As Plasma is one of the components of Blood, it performs an almost similar function as compared to Blood.

  • It maintains the electrolyte and fluid balance in the body.

  • It helps in immune function and clotting of the Blood.

  • It will serve as a protein reserve for the body.

  • It helps in the transportation of carbon dioxide, essential nutrients (organic, inorganic components and Plasma proteins), hormones (bound to Plasma proteins), waste (urea, uric acid, and creatinine), and other substances (for example drugs and alcohol) to and from the tissues.

Now, we have a basic idea about Blood and Plasma so let’s discuss the difference between Blood and Plasma.

Blood vs. Plasma Composition

Plasma and many types of cells make up blood, including red blood cells (erythrocytes), white blood cells (leukocytes), and thrombocytes (platelets). Blood has a density of 1060 kg/m3, which is quite similar to that of pure water (1000 kg/m3).

Except for red, white, and thrombocytes, plasma comprises 90% water, proteins (albumin, fibrinogen, and globulins), nutrients (glucose, fatty acids, amino acids), waste products (urea, uric acid, lactic acid, creatinine), clotting factors, minerals, immunoglobulins, hormones, and carbon dioxide. Components can be dissolved (if they're soluble) or they can stay bound to proteins (if insoluble). The density of plasma is 1025 kg/m3.

What is the Difference between Plasma and Blood?




Blood is the main body fluid that helps in the transportation of nutrients, oxygen, carbon dioxide, and waste products to carry out waste products. 

Plasma is the liquid component of the Blood excluding Blood cells.


It is composed of Plasma, WBC, RBC, and platelets.

It is composed of Water (90%), Protein, Nutrients, Waste products, Clotting factors, Minerals, Hormones, and Carbon dioxide. 


Blood is red in colour.

Plasma is straw- yellow in colour.


Blood contains the cells (Red, white) and platelets. 

Plasma does not contain any cells.

Storage of Blood and Plasma 

Blood is stored in the Blood banks which are used for Blood transfusion and the components of the Blood like platelets, Blood Plasma, and coagulation factors are stored and administered intravenously.

Blood Plasma is stored by freezing at -40 degrees celsius for 10 years and it can be used to treat the diseases relating to coagulation factor-like coagulopathies and liver diseases. Earlier it was used during World War II.

Functional Differences of Blood and Plasma

Blood serves a critical role in the human body. The following are the key functions:

  • Oxygen (attached to haemoglobin in red blood cells) and other vital nutrients are delivered to tissues.

  • Carbon dioxide and other waste materials are removed from tissues.

  • White blood cell circulation is critical for immunological processes.

  • Clotting at the site of an injury or a cut.

  • The body's temperature and pH are regulated.

Because plasma is a fluid component of blood, it performs all of the same activities as blood. It is particularly beneficial in the following areas:

  • Keeping the blood's electrolytes and hydration balance in check.

  • Serves as the body's protein reserve.

  • Aids in the coagulation of blood.

  • Immune system functions

  • Carbon dioxide, vital nutrients (organic, inorganic components, and plasma proteins), hormones (bound to plasma proteins), waste (urea, uric acid, and creatinine), and other substances (drugs and alcohol, for example) are transported to and from the tissues.


A blood disorder - Anemia, genetic disorders (thalassemia and sickle cell anaemia), leukaemia (blood cancer), haemophilia (inherited clotting disorder), infectious diseases (HIV, Hepatitis B and C, bacteremia, malaria, trypanosomiasis), and carbon monoxide poisoning are all examples of blood disorders. Dehydration, atherosclerosis, and other conditions are among the others.

Excessive drainage or fluid addition might induce volume alterations due to plasma shift. Changes in fluid volume across capillary membranes could be causing this volume variation. This shift can affect blood viscosity, protein content, red blood cell concentration, and coagulation factors, all of which can lead to clotting problems.

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FAQs on Difference Between Blood and Plasma

1. Does blood need to be healthy for Plasma donation?

Plasma transfusions are matched to keep away from A and B antibodies inside the transfused Plasma as a way to attack the recipient's red blood cells. Human beings with type AB blood are standard Plasma donors. Their Plasma does now not incorporate A or B antibodies and may be transfused properly to all blood sorts.

2. Why Blood is red in coloration?

Human blood is red in shade due to the presence of protein haemoglobin. Haemoglobin contains a red-colored compound referred to as heme which facilitates in wearing oxygen through the bloodstream.

3. Why is Plasma so vital?

The main role of Plasma is to take vitamins, hormones, and proteins to the elements of the frame that want it. Cells additionally placed their waste products into the Plasma. The Plasma then enables cast off this waste from the body. Blood Plasma additionally incorporates all parts of the blood via your circulatory system.

4. What's common among Blood and Plasma?

Both blood and Plasma have clotting. looking at the overall thing, each are additives of the fluid connective tissue which helps within the various functions of the body.

5. Is there a distinction among giving blood and Plasma?

Donating Plasma is a little distinct from donating entire blood. At the same time as you donate entire blood, it is going instantly into a set bag and is later separated in a lab.While you donate Plasma, the blood it's drawn from your arm is going through a special machine to separate the different parts of your blood.

6. Why is Blood Red in Colour?

Human blood is red in colour due to the presence of protein haemoglobin. Haemoglobin contains a red-coloured compound called heme which helps in carrying oxygen through the bloodstream.

7. What is Common Between Blood and Plasma?

Both blood and Plasma have clotting. Looking at the overall factor, both are components of the fluid connective tissue which helps in the various functions of the body.

8. What are the Diseases Caused by Blood and Plasma?

Blood disorders are anaemia, Genetic disorders, Leukemia, Hemophilia, Carbon monoxide poisoning, Infectious disorder, and some of the other disorders include dehydration, atherosclerosis, and others. In Plasma, excessive drainage or addition of fluid, it causes Plasma shift. This change could be caused by the change in fluid volume across capillary membranes. This may lead to a change in the coagulation factor which will cause coagulation disorders.