Courses
Courses for Kids
Free study material
Offline Centres
More
Store Icon
Store

Acromegaly Growth Hormone Excess in Adults

share icon
share icon
banner

What is acromegaly its causes symptoms diagnosis and management

Acromegaly Symptoms

A balanced hormone plays a substantial role in maintaining good health. There are various ailments related to hormonal fluctuations.  Though acromegaly is not a common hormonal illness around the world, there is no harm to be aware of acromegaly causes.  It is also essential to detect acromegaly symptoms for timely remedies. Let us begin with acromegaly definition.

 

What is Acromegaly?

Acromegaly begins with an unusual growth of hands, feet, and face.  You would not have difficulty in identifying acromegaly symptoms.  Though it may occur in older children, acromegaly is a condition, which occurs mostly in adults when their growth plates have closed.   Acromegaly is caused by excessive secretion of growth hormones, known as pituitary glands.

(Image to be added soon)

Image of the pituitary gland at the base of the brain

The Pituitary gland is a tiny, pea-sized gland located at the edge of the bony structure of the brain.  It occupies the place near your optic nerves.  Since it produces vital hormones for the body, it is also referred to as ‘Master Gland’. 


Acromegaly Symptoms 

(Image to be added soon) 

Image of deformed bones of the hand as a result of acromegaly

Acromegaly symptoms are visible and can be easily recognized.  When you realize that your ring does not fit in your finger because the shape of your hand has enlarged, you may want to consult a doctor as this could be the first of acromegaly symptoms.  Another acromegaly symptom could be visible when you begin to feel that you need a bigger shoe size.  Take a good look at yourself in the mirror, if you see that your jawline is protruding more than before.  A combination of all these acromegaly symptoms may be dropping hints for progressive acromegaly disease.  Acromegaly symptoms may differ from person to person.  However, if you can relate to nine out of ten symptoms, you may be suffering from acromegaly.

  • Over-size of jaws, nose, hands, legs, and so forth

  • Increased skin tags or outgrowth of skin

  • Fatigue and weakness in the muscles

  • Sinuses

  • Enlarged internal organs,

  • Larger tongue,

  • Pain in joints

  • Impaired vision

  • Rough or thickened skin,

  • Headache

  • Excess perspiration and body odor

  • Hair growth on the face in female

  • Snoring while sleeping

  • Change in voice

  • Irregular menstrual cycle

  • Dysfunction of erection in men

 

Acromegaly Causes

Now that you know what is acromegaly let us find out acromegaly causes.  Acromegaly is caused by surplus production of growth hormones by pituitary glands.  The excess secretion of growth hormones into your bloodstream activates the liver to manufacture insulin-like growth factors.  Though the growth plates in adults pause, these excessive growth factors trigger further enlargement of soft tissues and bones.  Hence, the resultant is giant-like growth in adults.   There are two reasons behind the acromegaly disorder.

  • Pituitary Tumours - Acromegaly is caused by a tumour of pituitary glands, which is noncancerous.  However, removal of this tumour would help in curing people with acromegaly disorder.  Since the tumours are located at the base of the brain, it puts pressure on the optic nerves, which leads to impaired vision and headaches.

  • Non-Pituitary Tumours – In other cases, acromegaly is caused by tumours in other internal organs, which includes lungs, pancreas, etc.  The tumours in other parts of the body trigger enlargement of internal organs.  Due to the overgrowth of the internal organs, you may feel discomfort.  With enlarged lungs, you may feel breathless. Overgrowth of the heart may lead to cardiovascular disease.  People with acromegaly disorder should also be watchful of pre-cancerous growths on the lining of the colon.  Early detection can prevent complications.

 

Fun Facts About Acromegaly

  1. Do you love reading books written by Ronald Dahl?   Acromegaly could remind you of the character of a giant from the children’s novel ‘The Big Friendly Giant’ written by Ronald Dahl.

  2. If you think, you will gain the right height if you suffer from acromegaly, then you are wrong.  Though children may grow tall, adults will not.  On the contrary, they will suffer from bone deformity. 

  3. The movie, ‘Honey, I blew up the kids!’ could remind you of gigantism, but not acromegaly.

  4. Complicated acromegaly could make you blind.

  5. The mastermind behind acromegaly is the master gland, also known as pituitary glands.

  6. You will find only a handful of acromegaly patients around the world since it is a rare disease.

Want to read offline? download full PDF here
Download full PDF
Is this page helpful?
like-imagedislike-image

FAQs on Acromegaly Growth Hormone Excess in Adults

1. What is acromegaly?

Acromegaly is a hormonal disorder caused by excessive secretion of growth hormone (GH) in adults, usually due to a pituitary adenoma. It occurs after the growth plates have closed, leading to enlargement of hands, feet, and facial bones rather than increased height.

  • Caused mainly by a benign tumor of the anterior pituitary gland
  • Results in excess production of insulin-like growth factor 1 (IGF-1)
  • Leads to progressive tissue and organ enlargement

2. What causes acromegaly?

Acromegaly is primarily caused by a growth hormone–secreting pituitary adenoma. In rare cases, it may result from tumors outside the pituitary that secrete growth hormone–releasing hormone (GHRH).

  • Benign tumor in the anterior pituitary (most common cause)
  • Excess GH stimulates the liver to produce IGF-1
  • Very rarely, ectopic GHRH-producing tumors

3. What are the main symptoms of acromegaly?

The main symptoms of acromegaly are enlargement of extremities and facial features due to prolonged excess growth hormone. Symptoms develop slowly over years.

  • Enlarged hands and feet
  • Coarsened facial features (large jaw, nose, lips)
  • Joint pain and thickened skin
  • Headaches and vision problems from tumor pressure
  • Organ enlargement such as cardiomegaly

4. How is acromegaly different from gigantism?

Acromegaly occurs after the closure of growth plates, while gigantism occurs before growth plate closure in children. Both are caused by excess growth hormone, but their effects differ.

  • Gigantism: Excessive height due to open epiphyseal plates
  • Acromegaly: Bone thickening and soft tissue growth without increased height
  • Both usually caused by a pituitary adenoma

5. How does excess growth hormone cause acromegaly?

Excess growth hormone (GH) stimulates the liver to produce high levels of IGF-1, which promotes abnormal growth of bones and soft tissues. The process occurs in steps:

  • GH overproduction by the pituitary tumor
  • Increased secretion of IGF-1 from the liver
  • Continuous stimulation of bone, cartilage, and organ growth
  • Thickening of tissues and enlargement of extremities

6. Which body systems are affected by acromegaly?

Acromegaly affects multiple body systems due to widespread action of excess growth hormone and IGF-1.

  • Skeletal system: Bone thickening and joint problems
  • Cardiovascular system: Cardiomegaly and hypertension
  • Metabolic system: Insulin resistance and diabetes mellitus
  • Nervous system: Headaches and visual field defects

7. How is acromegaly diagnosed?

Acromegaly is diagnosed by elevated IGF-1 levels and failure of growth hormone suppression during an oral glucose tolerance test. Imaging confirms the cause.

  • Blood test for high IGF-1
  • Oral glucose tolerance test (GH does not suppress)
  • MRI of the pituitary gland to detect adenoma

8. What complications can occur in untreated acromegaly?

Untreated acromegaly can lead to serious complications, especially affecting the heart and metabolism. Long-term excess growth hormone increases morbidity and mortality.

  • Cardiomyopathy and heart failure
  • Type 2 diabetes mellitus
  • Sleep apnea
  • Arthritis and joint degeneration
  • Increased risk of colorectal polyps

9. What is the role of the pituitary gland in acromegaly?

The pituitary gland plays a central role in acromegaly because it produces excessive growth hormone, usually due to a benign tumor. The anterior pituitary loses normal regulatory control.

  • Contains GH-secreting cells called somatotrophs
  • Tumor causes continuous GH release
  • Leads to elevated IGF-1 and systemic tissue growth

10. Can acromegaly be treated or cured?

Acromegaly can often be effectively treated and sometimes cured, especially if the pituitary adenoma is removed early. Treatment aims to normalize growth hormone and IGF-1 levels.

  • Surgical removal of the pituitary tumor (first-line treatment)
  • Medications such as somatostatin analogs or GH receptor antagonists
  • Radiation therapy in selected cases


Competitive Exams after 12th Science
tp-imag
bottom-arrow
tp-imag
bottom-arrow
tp-imag
bottom-arrow
tp-imag
bottom-arrow
tp-imag
bottom-arrow
tp-imag
bottom-arrow