Question

A reaction of ethyl amine and acetic anhydride leads to the formation of:
(A) $C{{H}_{3}}NHCOC{{H}_{3}}$
(B) ${{C}_{2}}{{H}_{5}}CONHC{{H}_{3}}$
(C) $C{{H}_{3}}CONH{{C}_{2}}{{H}_{5}}$
(D) $C{{H}_{3}}-CH=NO{{C}_{2}}{{H}_{5}}$

Answer 1

Hint: A reaction of ethyl amine and acetic anhydride is an acetylation reaction. An acetylation reaction is the reaction in which an acetyl group is introduced into a compound. This reaction can occur by the addition of acetic anhydride or acetyl chloride. It is a nucleophilic substitution reaction. This reaction is also known as ethanoylation.

Complete Step by Step Answer:
The ethyl amine consists of an ethyl group attached to a $N{{H}_{2}}$ group. When the acetylation reaction of ethyl amine takes place by the addition of acetic anhydride, N-ethyl acetamide is formed. The chemical formula of N-ethyl acetamide is $C{{H}_{3}}CONH{{C}_{2}}{{H}_{5}}$. Nitrogen atoms of ethyl amine are acetylated in this reaction. In this reaction, one of the hydrogen atoms of the $N{{H}_{2}}$ group is replaced by an acetyl group.

Correct Option: (C)$C{{H}_{3}}CONH{{C}_{2}}{{H}_{5}}$.

Additional Information: Many compounds like aspirin and proteins can be synthesised with the help of an acetylation reaction. These reactions play a crucial role in drug biotransformation, which is the acetylation reaction-aided processing and elimination of medicines by the body. The inverse reaction, which is the reaction in which the acetyl group is removed completely, is known as the deacetylation reaction.

Note: Acetylation is a modification that can significantly modify a protein's function by changing its hydrophobicity, solubility, and surface characteristics. These changes may have an impact on the protein's conformation and interactions with substrates, cofactors, and other macromolecules.