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Second-generation vaccine is
(A)Smallpox vaccine
(B)DPT vaccine
(C)Hepatitis B vaccine
(D)Polio vaccine

Last updated date: 11th Jun 2024
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Hint: There are three generations of vaccines, the first one using live organisms whereas the other two use modern techniques like recombination and DNA. Second-generation vaccines were mainly made due to the risk involved in using live organisms as vaccines.

Complete answer:
The hepatitis-B vaccine is a second-generation vaccine.
The second-generation vaccine or recombinant vaccine is made by genetic engineering in order to prevent the risk developed from the use of live organisms in first-generation vaccines.
Hepatitis-B vaccines are developed from recombinant DNA technology to reduce risk from the live vaccines used earlier for treatment.

Additional Information:
Hepatitis-B is a liver infection that is caused by the HBV (Hepatitis-B virus) and is spread by the transfer of blood, semen or other body fluid from an infected person to a normal person.
Smallpox is also a virus-borne disease that used to be contagious and often deadly but now it is announced as globally eradicated by WHO.
DPT is short of Diphtheria, pertussis, and tetanus- three infectious diseases in humans. Diphtheria is caused by Corynebacterium diphtheria, pertussis is caused by Bordetella pertussis, and tetanus is caused by Clostridium tetani.
Polio is another life-threatening disease caused by a virus named Poliovirus which spreads from person to person and causes paralysis.
So, the correct answer is the option (C) "Hepatitis B vaccine".

Note: There are three types of vaccines- first generation, second generation, and third generation vaccines. First generations are live and weakened or killed organism vaccines. Some examples are smallpox and polio vaccines. Second generation or recombinant vaccines are developed to reduce risk from the first generation ones. Some examples- tetanus, Diphtheria, etc. Third generations are DNA vaccines such as vaccines for the zika virus.