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What observations suggest a cyclic structure for the glucose molecule?

Last updated date: 21st Jul 2024
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Hint: Glucose, also known as dextrose, is a type of carbohydrate that belongs to the group of carbohydrates known as simple sugars. \[{C_6}{H_{12}}{O_6}\] is the chemical formula for glucose. It's found in fruits and honey, and it's the most common free sugar in higher animals' blood.

Complete answer:
Alcohols and aldehydes and ketones are believed to form hemiacetals and acetals. Acetals are more resistant to nucleophilic attack and simple solutions.
 Glucose comes in two different forms $\alpha $ and $\beta $ : and. Both undergo ‘Mutarotation' equilibration in solution and have the same optical rotation of $52.7$ .
The aldehyde and hydroxyl group of glucose will form intramolecular hemiacetal and acetals, much like an aldehyde and alcohol mixture.
The construction of a very stable six-membered cyclic structure by cyclic hemiacetal formation between the aldehyde and the hydroxyl group of the fifth carbon atom. The cyclic structure is similar to that of pyran, a heterocyclic compound with a six-membered ring.
Glucopyranose is the name given to this cyclic arrangement. Bending the glucose chain, then rotating the fourth and fifth carbon bonds, puts the $C-5$ -hydroxyl group and the aldehyde groups closer together, forming a six-membered hemiacetal. Glucose has a six-membered hemiacetal form that can be drawn as a flat hexagon. (HAWORTH FORMULA). However, due to the hybridization, the glucose molecule cannot be planar. It may take three different forms: chair, boat, or skew, both of which are relatively stable in the same order.
Anomeric carbon refers to the hemiacetal carbon atom $(C - 1)$ which is a new stereogenic centre. The hemiacetal can take two forms (anomers) depending on the direction of the $OH$ groups at this anomeric carbon: - $\alpha - glucose$ and $\beta - glucose$ . If the hydroxyl group is above the plane, the structure is called $\beta - form$ , and if it is below the plane, it is called $\alpha - form$ . In solution, both the cyclic hemiacetals (anomers) and the open-chain form are in equilibrium.

Glucose is the most common form of sugar in the blood and the body's primary source of energy. Glucose is derived from the foods we consume or produced by the body from other compounds. The plasma transports glucose to the cells. Several hormones, including insulin, regulate blood glucose levels.