Answer
424.2k+ views
Hint: The Hoffmann's Bromamide reaction uses a halogen, a base, water and heat for it to take place. Amines are the functional group which are a derivative of ammonia but one or more hydrogen are replaced by an alkyl group or an aryl group. Amide is a functional group that has a carbonyl attached to a nitrogen atom.
Complete answer step by step: Hoffmann Bromamide reaction mechanism is a reaction that is used to convert a primary amide into a primary amine with one less carbon. This reaction uses an alkali as a strong base which attacks the amide which leads to the deprotonation and generation of an anion.
The Hoffmann' Bromamide reaction can be written as follows:
$RCON{ H }_{ 2 }\quad +\quad B{ r }_{ 2 }\quad +\quad 4NaOH\quad \rightarrow \quad R-N{ H }_{ 2\quad }\quad +\quad N{ a }_{ 2 }C{ O }_{ 3 }\quad +\quad 2NaBr\quad +\quad 2{ H }_{ 2 }O$
The reaction proceeds with the attack of a strong base on the amide, which leads to deprotonation and generating an anion.
The anion formed reacts with the bromine to form N-bromamide and this reaction is known as $\alpha$-substitution reaction.
Then deprotonation of bromamide molecules takes place to form bromamide anion.
This anion undergoes rearrangement such that the R group which was attached to the carbonyl carbon migrates to nitrogen. Simultaneously the bromide ion leaves the compound forming isocyanate.
Water molecules get added to isocyanate to form carbamic acid.
Finally, this carbamic acid releases carbon dioxide, leading to the formation of primary amine.
Note: Deprotonation refers to the removal/transfer of a proton from a bronsted lowry acid in an acid base reaction. This forms the conjugate base of that acid which was deprotonated.
Complete answer step by step: Hoffmann Bromamide reaction mechanism is a reaction that is used to convert a primary amide into a primary amine with one less carbon. This reaction uses an alkali as a strong base which attacks the amide which leads to the deprotonation and generation of an anion.
The Hoffmann' Bromamide reaction can be written as follows:
$RCON{ H }_{ 2 }\quad +\quad B{ r }_{ 2 }\quad +\quad 4NaOH\quad \rightarrow \quad R-N{ H }_{ 2\quad }\quad +\quad N{ a }_{ 2 }C{ O }_{ 3 }\quad +\quad 2NaBr\quad +\quad 2{ H }_{ 2 }O$
![seo images](https://www.vedantu.com/question-sets/f23ee0e4-4b81-4b9e-94a0-20bd5dc9eb791670140931082097681.png)
The reaction proceeds with the attack of a strong base on the amide, which leads to deprotonation and generating an anion.
The anion formed reacts with the bromine to form N-bromamide and this reaction is known as $\alpha$-substitution reaction.
Then deprotonation of bromamide molecules takes place to form bromamide anion.
This anion undergoes rearrangement such that the R group which was attached to the carbonyl carbon migrates to nitrogen. Simultaneously the bromide ion leaves the compound forming isocyanate.
Water molecules get added to isocyanate to form carbamic acid.
Finally, this carbamic acid releases carbon dioxide, leading to the formation of primary amine.
Note: Deprotonation refers to the removal/transfer of a proton from a bronsted lowry acid in an acid base reaction. This forms the conjugate base of that acid which was deprotonated.
Recently Updated Pages
How many sigma and pi bonds are present in HCequiv class 11 chemistry CBSE
![arrow-right](/cdn/images/seo-templates/arrow-right.png)
Why Are Noble Gases NonReactive class 11 chemistry CBSE
![arrow-right](/cdn/images/seo-templates/arrow-right.png)
Let X and Y be the sets of all positive divisors of class 11 maths CBSE
![arrow-right](/cdn/images/seo-templates/arrow-right.png)
Let x and y be 2 real numbers which satisfy the equations class 11 maths CBSE
![arrow-right](/cdn/images/seo-templates/arrow-right.png)
Let x 4log 2sqrt 9k 1 + 7 and y dfrac132log 2sqrt5 class 11 maths CBSE
![arrow-right](/cdn/images/seo-templates/arrow-right.png)
Let x22ax+b20 and x22bx+a20 be two equations Then the class 11 maths CBSE
![arrow-right](/cdn/images/seo-templates/arrow-right.png)
Trending doubts
Fill the blanks with the suitable prepositions 1 The class 9 english CBSE
![arrow-right](/cdn/images/seo-templates/arrow-right.png)
At which age domestication of animals started A Neolithic class 11 social science CBSE
![arrow-right](/cdn/images/seo-templates/arrow-right.png)
Which are the Top 10 Largest Countries of the World?
![arrow-right](/cdn/images/seo-templates/arrow-right.png)
Give 10 examples for herbs , shrubs , climbers , creepers
![arrow-right](/cdn/images/seo-templates/arrow-right.png)
Difference between Prokaryotic cell and Eukaryotic class 11 biology CBSE
![arrow-right](/cdn/images/seo-templates/arrow-right.png)
Difference Between Plant Cell and Animal Cell
![arrow-right](/cdn/images/seo-templates/arrow-right.png)
Write a letter to the principal requesting him to grant class 10 english CBSE
![arrow-right](/cdn/images/seo-templates/arrow-right.png)
Change the following sentences into negative and interrogative class 10 english CBSE
![arrow-right](/cdn/images/seo-templates/arrow-right.png)
Fill in the blanks A 1 lakh ten thousand B 1 million class 9 maths CBSE
![arrow-right](/cdn/images/seo-templates/arrow-right.png)