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Difference Between Spermatogenesis and Oogenesis

Last updated date: 22nd Feb 2024
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What is Spermatogenesis and Oogenesis?: An Introduction

Gametogenesis, the process by which specialized cells called gametes (sperm and eggs) are produced, plays a crucial role in sexual reproduction. Spermatogenesis involves the production of sperm cells in males. It is a continuous and highly prolific process that occurs throughout a male’s reproductive life. In contrast, oogenesis involves the production of egg cells in females. It is a cyclic process that starts during fetal development, but pauses until puberty and concludes with menopause. 

Both these processes involve the formation of haploid gametes from diploid precursor cells through a series of cellular divisions. However, the timing, location, and mechanisms involved in these processes differ significantly between males and females. In this article, the unique characteristics of spermatogenesis and oogenesis are explored in depth.

Characteristics of Spermatogenesis and Oogenesis

Occurrence: Spermatogenesis occurs in the testes of males, while oogenesis occurs in the ovaries of females.

Cellular Location: Spermatogenesis takes place within the seminiferous tubules, which are highly coiled structures within the testes. The seminiferous tubules contain specialized cells called Sertoli cells, that provide support and nourishment to developing sperm cells. Oogenesis takes place within the ovarian follicles, which are small fluid-filled sacs within the ovaries. The ovarian follicles consist of specialized cells called granulosa cells that surround and support the developing oocytes (immature eggs). 

Cellular Division: Spermatogenesis involves both mitotic and meiotic division, while oogenesis involves only meiotic division.

Key Stages Involved in Spermatogenesis

Spermatogenesis is the process by which sperm cells, or spermatozoa, are produced in the testes of male organisms, specifically within structures called seminiferous tubules. It is a complex and highly regulated process that involves several stages.

  • Primordial germ cells are cells that will eventually become sperm cells. They originate in the embryo and migrate to the developing testes.

  • Once the primordial germ cells reach the testes, they differentiate into spermatogonia. These are the stem cells of spermatogenesis and reside near the basement membrane of the seminiferous tubules.

  • Spermatogonia undergo mitotic division and increase in number. One of the resulting cells remains as a spermatogonium for further division, while the other cell becomes a primary spermatocyte.

  • The primary spermatocyte undergoes meiosis I, resulting in two haploid secondary spermatocytes. Each secondary spermatocyte then undergoes meiosis II, to produce a total of four haploid spermatids.

  • Spermatids undergo a process called spermiogenesis, during which they undergo morphological changes to develop into mature sperm cells. This involves the formation of the acrosome, condensation of the nucleus, development of the flagellum (tail), and shedding of excess cytoplasm.

  • Finally, mature sperm cells are released into the lumen of the seminiferous tubules. They then pass through the epididymis and other reproductive ducts, where they undergo further maturation and become capable of fertilization.

Key Stages Involved in Oogenesis

Oogenesis is the process by which ova (eggs) are produced in the ovaries of female organisms. It is a highly regulated process that involves the following stages.

  • In the early stages of fetal development, the germ cells in the ovaries called oogonia multiply through mitosis to form a large pool of cells. 

  • Some of the oogonia develop into primary oocytes, which enter a state of meiotic arrest known as prophase I. These primary oocytes are surrounded by a layer of follicular cells to form a primordial follicle.

  • At the onset of puberty, a small number of primordial follicles mature. During each menstrual cycle, one follicle is selected for further development into a secondary follicle, while others undergo degeneration. 

  • The secondary follicle further matures as the Graafian follicle, which contains a mature oocyte. Around the middle of the menstrual cycle, the Graafian follicle ruptures, releasing the oocyte into the fallopian tube in a process called ovulation.

  • Once the oocyte is released, it enters meiosis II, but this process is arrested at metaphase II until fertilization occurs. 

  • If fertilization occurs, the oocyte completes meiosis II, resulting in the formation of a mature egg and the extrusion of a second polar body. If fertilization does not occur, the unfertilized egg, along with the surrounding follicular cells degenerate.

Difference Between Spermatogenesis and Oogenesis 






It is the process of formation of male gametes: sperm.

It is the process of formation of female gametes: egg.


It occurs in the testes of male organisms, within the seminiferous tubules.

It occurs in the ovaries of female organisms, within the ovarian follicles.

Functional Cell

Spermatozoa is the functional cell and four of them are produced.

The ovum is the functional cell and only one ovum is produced.


Sperms are motile.

The ovum is not motile.


It is a continuous process that starts during puberty and shows a short growth phase.

It is a cyclic process that starts before birth and shows a long growth phase.

Cell Division

All spermatozoa are produced by meiosis. Sperms are produced continuously.

Oogonia divides during the production of eggs. At a time, only one egg is produced.

Nuclear Condensation

The nucleus of the sperm shows condensation.

The nucleus of the ovum does not show condensation.

Reserved Food

The sperm reserves less amount of food.

The ovum can store a lot of food and biochemicals.


Gametogenesis in the human body occurs through two main processes: spermatogenesis and oogenesis. Sperms are produced in the testes of males by a process called spermatogenesis and ova is produced in the ovaries of females by a process called oogenesis. In conclusion, this article sheds light on the processes of spermatogenesis and oogenesis. By understanding the difference between spermatogenesis and oogenesis, one can gain valuable insights into the fundamental principles of sexual reproduction.

FAQs on Difference Between Spermatogenesis and Oogenesis

1. Explain Spermatogenesis and Oogenesis.

Spermatogenesis and oogenesis are the processes of gametogenesis, which involve the formation and development of specialised reproductive cells called gametes. Spermatogenesis is the process of sperm cell development in males, involving the continuous production of sperm cells throughout a man’s life. Oogenesis is the process of egg cell development in females, occurring cyclically with the formation of a limited number of eggs during a women’s reproductive lifespan.

2. What is the Difference Between Sperm and Ovum?

Sperm and ovum are the two gametes produced in vertebrates. The sperm, the male gamete, is produced in the testes of males and contains X or Y chromosomes. On the other hand, the ovum, the female gamete, is produced in the ovaries of females and contains only X chromosomes.

3. Why is it Important to Know Spermatogenesis and Oogenesis Difference?

Understanding the differences between spermatogenesis and oogenesis is important for reproductive health, birth control, family planning, diagnosing infertility, understanding genetic inheritance, and advancing our understanding of developmental biology. Understanding the mechanisms of genetic variation in spermatogenesis and oogenesis helps in comprehending patterns of inheritance and the transmission of genetic traits from parents to offspring.