Question 3: Describe the Perkin Reaction and the Mechanism of Perkins’s Reaction.
Answer: Perkin Reaction is a type of chemical reaction that involves the aldol condensation of an organic acid anhydride and an aromatic aldehyde to yield an ɑ, 𝛃-unsaturated aromatic acid.
Benzaldehyde when heated with acetic anhydride in the presence of sodium acetate it forms cinnamic acid as a product.
C2 H5 CH=O + CH−CO−O−COCH3 → C5H5CH=CH−COOH + CH3 COOH3Perkins’s condensation mechanism consists of five steps. The first step involves deprotonation using a weak base. The second step involves the formation of a carbanion. The third step involves the Attack of this carbanion on the carbon of the carbonyl compound. The fourth step involves condensation and the last step involves hydrolysis which results in the formation of the final product.