Question

Trade name of genetically engineered insulin is
(a) Beta insulin
(b) Humulin
(c) Anulin
(d) Gilbert’s insulin

Answer 1

Hint:
A trade name is also called a trading name, or business name. It is a professional name used by companies that do not work under their registered (record) company name. Eli Lily, an American company produced two chains of insulin.

Complete step by step answer:
Insulin used for diabetes was earlier extracted from the pancreas of slaughtered cattle and pigs which caused allergic reactions in some patients Chain A and chain B are the two short polypeptide chains that are joined by disulfide bridges. In mammals including humans, insulin is synthesized as a prohormone, the prohormone needs to be processed before it becomes a fully mature and functional hormone. Which contains an extra stretch called C peptide.
In mature insulin, the C peptide is not present. During the maturation of insulin, it is removed. An American company in 1983, Eli lily made two DNA sequences correlated with A and B chains of human insulin and then put them in E.coli plasmid. This plasmid replicates itself and also replicates the A and B chains. So chain A and chain B were produced individually, extracted and by forming disulphide bonds to form human insulin and combine them. Genetically engineered insulin is called Humulin.

Option ‘B’ is correct

Note:
Bentin and Best extracted insulin from beta cells of the islet of Langerhans. The instructions for producing the hormone insulin are given by the INS gene which is important to control levels of glucose in the blood.