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Gamete Intrafallopian Transfer (GIFT): Full Form, Procedure, & Benefits

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Intro to GIFT and its full form

GIFT stands for Gamete Intrafallopian Transfer, an assisted reproductive technology (ART) designed to help couples struggling with infertility. Unlike IVF (In Vitro Fertilization), where fertilization occurs in a laboratory, GIFT allows fertilization to happen naturally inside the fallopian tubes. 

In this procedure, eggs and sperm (gametes) are collected, mixed, and then directly transferred into the fallopian tubes using a minimally invasive laparoscopic technique. GIFT is often recommended for couples with unexplained infertility, religious or ethical concerns about lab-based fertilization, or those with healthy fallopian tubes. It mimics the natural fertilization process, offering a more holistic approach to conception while still leveraging modern medical advancements. This method requires precise timing and expertise but can be a successful option for the right candidates.


How Does Gamete Intrafallopian Transfer (GIFT) Work?

GIFT facilitates fertilization in the body by placing the gametes (eggs and sperm) into the fallopian tube, where the natural environment supports fertilization and early embryo development.


Who Can Benefit from GIFT?

GIFT is suitable for:

  • Women with healthy fallopian tubes.

  • Couples facing unexplained infertility.

  • Individuals with ethical or religious concerns about IVF.

  • Cases where ovulation induction treatments or IUI (Intrauterine Insemination) have failed.


The Procedure of GIFT: Step-by-Step

  1. Ovarian Stimulation: Fertility medications are used to stimulate the ovaries to produce multiple eggs.

  2. Egg Retrieval: Eggs are collected from the ovaries through a minimally invasive procedure.

  3. Preparation of Gametes: The eggs and sperm are combined in a catheter.

  4. Transfer to Fallopian Tubes: Using a laparoscopic procedure, the gametes are placed in the fallopian tube.

  5. Natural Fertilization: Fertilization occurs naturally within the fallopian tube, and the resulting embryo travels to the uterus for implantation.


Advantages of GIFT

  • Mimics the natural fertilization process.

  • No lab-based fertilization, making it suitable for individuals with ethical concerns about IVF.

  • High success rate in select cases, especially for younger couples with healthy fallopian tubes.


Risks and Limitations of GIFT

  • Requires healthy fallopian tubes.

  • Invasive compared to simpler procedures like IUI.

  • Increased risk of multiple pregnancies due to multiple egg transfers.

  • Not suitable for severe male infertility or women with damaged fallopian tubes.


Comparison of GIFT with Other Fertility Treatments

Aspect

GIFT

IVF

IUI

Fertilization Site

Inside fallopian tubes

In the lab

Inside the uterus

Procedure Type

Laparoscopy required

Non-surgical (egg collection)

Non-surgical

Success Rate

Moderate to High (select cases)

High (varies by age)

Moderate

Ethical Concerns

Minimal

Possible (lab-based fertilization)

None


Cost of GIFT in India

The cost of GIFT typically ranges between ₹1,00,000 and ₹2,50,000, depending on the clinic and location.

Conclusion

Gamete Intrafallopian Transfer (GIFT) is a valuable fertility treatment option for couples struggling with infertility, particularly those seeking a more natural fertilization process. While it requires healthy fallopian tubes and has some limitations, its advantages and ethical appeal make it an important alternative to IVF. Consulting with a fertility specialist can help determine if GIFT is the right option for you.


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FAQs on Gamete Intrafallopian Transfer (GIFT): Full Form, Procedure, & Benefits

1. What is the full form of GIFT?


GIFT stands for Gamete Intrafallopian Transfer, an assisted reproductive technology.

2. How is GIFT different from IVF?


In GIFT, fertilization occurs inside the body, while in IVF, it takes place outside in a laboratory.


3. Who is a candidate for GIFT?


Women with at least one functional fallopian tube and couples with unexplained infertility are ideal candidates.


4. What are the risks of GIFT?


Risks include surgical complications, ectopic pregnancy, and ovarian hyperstimulation syndrome.

5. What is the success rate of GIFT?


The success rate is 25–30% per cycle, depending on various factors like age and egg quality.


6. Why is GIFT less common today?

Advances in IVF, which offer higher success rates and no invasive surgery, have made GIFT less popular.


7. Is GIFT ethical?


GIFT is often preferred by couples with ethical or religious concerns about external fertilization.


8. How long does a GIFT cycle take?

A GIFT cycle typically takes 4–6 weeks, including ovarian stimulation, monitoring, and the procedure.


9. Can GIFT lead to multiple pregnancies?


Yes, transferring multiple eggs increases the chances of twins or triplets.


10. What are the costs involved in GIFT?


GIFT is expensive due to fertility medications, monitoring, and surgical procedures.