Question

In patients with haemophilia, which of these can increase the risk of cerebral microbleeds?
A. Cardiovascular risk factor
B. Increased age
C. Hepatitis C infection
D. All of these

Answer 1

Hint:
Before we proceed into the problem, it is important to know about haemophilia.
Haemophilia is a clinically and genetically multicultural blood disorder, with several known gene defects that account for inflation for the disease phenotype and inhibitor production diversity. Although an increasing number of people with causative mutations have been identified, little is known about the root cause of inhibitor development against infused blood clot-form factors.

Complete step by step answer:
Molecular genetics has been implicated in the pathogenesis of haemophilia since the discovery of mutations in innate vitamin k deficiency. Several point mutations that cause HA or HB have been recognized in various ethnic groups over the last few decades.
Haemophilia is a complex X-linked blood disorder with multiple mutations that contribute to its pathogenetic. Because the only affordable treatment for this disease is the substitute for deficient blood coagulation, the development of inhibitors against infused factors represents a major challenge in treatment, with a high risk of morbidity and mortality.
Therefore, the risk can be caused by Cardiovascular risk factors, Increased age, and Hepatitis C infection.

Option ‘D’ is correct

Note:
Cerebral microbleeds are especially a concern in PWH because spontaneous and traumatic intracerebral haemorrhages are more prevalent. Moreover, PWH now receives better medical care and lives longer existences, which leads to the acquisition of other risk factors. PWH seem to be more likely than others to develop hypertension, which also increases their risk of cerebral microbleeds.