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**Hint:**a locus (Latin word for "place", "location") is a set of all points (commonly, a line, line segment a curve, or a surface) whose location satisfies or is determined by one or more specified conditions. In other words, the set of points that satisfy some property is often called the locus of a point satisfying this property.

The locus of a point P is such that it is equidistant from two given points. A and B i.e. PA=PB. The locus of a point at fixed distance d, from point P, is a circle with given point P as its center and d as its radius. Here in this question, we can use the distance formula for two given points.

Distance formula = \[\sqrt {{{(x_2 - x_1)}^2} + {{(y_2 - y_1)}^2}} \]

**Complete step by step answer:**

Let the point be \[(p,q)\]

\[B{C^2} = A{B^2} + A{C^2}\](By Pythagoras theorem)

\[{(4 - 0)^2} + {(0 - 4)^2} = {(p - 0)^2} + {(q - 4)^2} + {(p - 4)^2} + {(q - 0)^2}\]

\[16 + 16 = {p^2} + {q^2} + 16 - 8q + {p^2} + 16 - 8p + {q^2}\]

\[32 = 2({p^2} + {q^2} - 4p - 4q) + 32\]

Or \[{p^2} + {q^2} - 4p - 4q = 0\]

Replacing \[p \to x\]and \[q \to y\]

\[{x^2} + {y^2} - 4x - 4y = 0\] is the locus of the equation.

**Note:**we can also find this finding slope of two lines AB as \[m_1 = \dfrac{{y_2 - y_1}}{{x_2 - x_1}}\], and AC as \[m_2 = \dfrac{{y_2 - y_1}}{{x_2 - x_1}}\]

And for perpendicular lines\[{m_1}{m_2} = - 1\]

We get the required locus of the third vertex.

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