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Which one is not a cofactor?
A. Coenzyme
B. Metal ions
C. Apoenzyme
D. Prosthetic group

Last updated date: 05th Mar 2024
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IVSAT 2024
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Hint: Cofactors are any non-protein substances required for a protein to have catalytic activity. Some cofactors are inorganic, such as metal atoms zinc, iron and copper in various oxidation states. Other vitamins (such as most vitamins) are organic.

Complete Answer:
Coenzyme: Coenzymes are organic non-protein compounds that combine with enzymes to catalyze reactions. Coenzymes are often widely referred to as cofactors, but they are chemically different. Coenzymes cannot work alone, but they can be used repeatedly after pairing with enzymes.

Prosthetic group: The Repair groups are specific non-polypeptide units that are tightly bound for the biological functions of certain proteins. Prosthetic groups can be organic (for example, vitamins, sugars or lipids) or inorganic (for example, metal ions), but do not consist of amino acids.

Metal ions: A formed by removing one or more external electrons from neutral atoms. The energy required for ion formation depends on the environment in which the metal is located. The formation of ions in the gas phase requires a lot of energy.

Apoenzyme: The inactive enzyme, the activation of the enzyme occurs after the combination of organic or inorganic cofactors. Holoenzyme-deco enzyme and its cofactors. The whole enzyme is complete and has catalytic activity. Most cofactors are not covalently bound, but tightly bound.

Thus, the option (C) is correct.

Note: Coenzymes are organic molecules, and when they are tightly bound to each other, they are called prosthetic groups. Apoenzymes are described as enzymes that do not contain any enzymatic activity of coenzyme molecules, so they are called inactive enzymes.
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