Question

What is released in the body during disease which results in fever?
A) Pyrogens
B) Antibodies
C) Interferons
D) Interleukins

Answer 1

Hint: A fever results in rise of body temperature temporarily. It’s a part of an overall response from the body’s immune system. A fever is caused by an infection. Fever is a sign that our body is not alright and there must be any infection or disease.


Complete step-by-step answer:
 Pyrogens are the substances released by bacteria during fever. Antibodies are released when a foreign particle invades our immune system an antigen-antibody complex is formed and the invading antigen killing takes place. Antibodies are also called immunoglobulins these are antigen-binding glycoproteins belonging to the immunoglobulin superfamily synthesized exclusively by B cells.
Interferons are released by virus-infected cells. Suppose two cells are attached so that if the virus infects one cell then it releases interferons so that the other cell gets protected from infection and this cell will kill the virus as soon as it enters the cell. Interleukins are cytokines and these are present in our immune system and play a major role to protect our immune system. Interleukins are secreted by a variety of leukocytes. They promote the development and differentiation of T cells, B cells, and hematopoietic cells.


Therefore the correct answer is Option A.


Note: Usually within two hours of exposure, Exogenous pyrogens like bacteria, viruses, and toxins initiate fever, by interacting with the macrophages or monocytes, leading to cytokine induction. Other mechanisms to initiate fever include some endotoxins, produced by bacteria, which act directly on the hypothalamus to alter the set point.