Question

Modifications by germline gene therapy are heritable as:
(A) The functional gene is incorporated into their genome.
(B) The functional gene is incorporated into one of the genes.
(C) The functional gene is incorporated into somatic cells.
(D) All the above

Answer 1

Hint: DNA from reproductive cells (egg or sperm) is referred to as "germline DNA" and is absorbed into every cell in the body of the progeny. Parental inheritance of a germline mutation is possible.

Step by step solution:

DNA is injected into the human body's reproductive cells (eggs or sperm) during germline gene therapy. The genetic variations of a person's reproductive cells will be corrected through germline gene therapy, and this will be passed on to subsequent generations. A height advantage, better physical characteristics, and as-yet-undefined intellectual attributes are typical examples. Of course, there is the issue of "tinkering with nature," which many people perceive to be immoral. Early research indicated very substantial health hazards associated with gene therapy, including toxicity, inflammation, and malignancy. Since then, scientists have investigated the causes and created more dependable procedures that are less likely to result in harmful immune responses or cancer. Germline genome editing raises several bioethical concerns, including the possibility of unintended modifications to the genome, who should provide informed consent, how to do so, and the breeding of the human species (eugenics).
So, option (A) is correct.
Note: In somatic cells, genes can be added or changed as part of somatic gene therapy. The introduction or modification of genes in germ cells is referred to as germline gene therapy. Given that it attacks the root of the problem, gene therapy is currently a promising area of medicine.