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Interference in development and maturation for RBC is caused by
A. $Hg$ pollution
B. $Pb$ pollution
C. $S$ pollution
D. All of these

seo-qna
Last updated date: 03rd Mar 2024
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IVSAT 2024
Answer
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Hint: The erythropoiesis is process of formation of red blood cell, that is development from erythropoietic stem cell to mature red blood cells, level of $O_2$ circulation stimulates the erythropoiesis, that is detected by kidney which release hormone erythropoietin. Which increases the erythropoiesis.

Complete answer:
In our modern environment, various kind of heavy metal($Hg, Pb, As, Cr, Cd$) are found and may enter into our body through various route, which interfere with our body metabolic activities and cause various kind of diseases, Pb(lead) is the heavy metal which show interference during the development and maturation of RBCs. Pb interferes with heme synthesis and causes hematological damage by inhibiting several key enzymes in the process of heme synthesis.

Hg- This symbol represents the mercury element which is liquid at room temperature, mercury is toxic heavy metal and causes various metabolic disorders and causes cancer. Mercury toxicity causes minamata disease, which is neurological syndrome. Minamata is caused by methylmercury poisoning, which is the most toxic form, and elemental mercury is less toxic. Mercury toxicity can cause paralysis, genetic drift.

S- It represents the Sulphur, which is a non-metal element which is an important element because it is found in the amino acid name as cysteine and methionine which are required in the formation of polypeptide chains of protein.

Hence, the correct answer is option (A).

Note: Disruption or improper formation of RBC can be caused by various kinds of factors like heavy metal accumulation or genetic drift like sickle cell anemia. Erythropoiesis occurs in red bone marrow in mammals, but this process also takes place in the spleen and liver, which is characterized as extramedullary erythropoiesis.
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