Question

In alcoholics, liver cells come to accumulate fat. Fat formation is stimulated by
A)Alcohol
B)Acetaldehyde
C)Thiamine deficiency
D)Folic acid deficiency

Answer 1

Hint: The use of alcohol during adolescence can cause long term effects. It could lead to heavy drinking in adulthood. The chronic use of alcohol damages the nervous system and liver and is termed as
Liver cirrhosis

Complete answer:
Absorbed alcohol is taken directly to the liver, where it gets converted to the preferred fuel. Use of medium amounts of alcohol does not cause liver damage, but the condition is adequate nutrition is maintained. However, chronic alcoholism causes some diseases namely Alcoholic fatty liver. The liver becomes enlarged, and yellow in colour, greasy and firm. Hepatocytes (cells of liver) are distended by large fat globules which push and make the hepatocyte nucleus against the cell membrane. There is an increase in the fat synthesis in the liver.

Now let us find solution from given options:
Alcohol : Fat formation is not directly led by alcohol but it occurs due to the formation of some different substances from alcohol.
Acetaldehyde : When alcohol is consumed in a large amount it gets converted to acetaldehyde in the liver and this acetaldehyde causes the fatty liver.
Thiamine deficiency : When thiamine deficiency occurs that is less amount of vitamin B1 is secreted it can lead to a disease that is commonly called as beriberi and not fatty liver.
Folic acid deficiency : Folic acid is particularly a vitamin B. When there is less production of vitamin B or folic acid it leads to less production of red blood cells and thereby causes anaemia.

Hence, the correct answer is option (B)

Note: High doses of alcohol cause ill effect on gastric glands of stomach, these glands secrete gastric juices in excess which cause the inflammation to gastric mucosa. This condition is known as gastritis. It may also result in gastric carcinoma, peptic ulcer. Dilute alcohol (optimum 10%) stimulates and increases gastric secretion (especially acid). Acute alcoholic intake can result in inflammation of the oesophagus (oesophagitis) and stomach (gastritis).