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Exophthalmic goitre is due to
A. Hyposecretion of thyroxine
B. Hypersecretion of thyroxine
C. Hypersecretion of thyrocalcitonin
D. Hyposecretion of thyrocalcitonin

Last updated date: 16th Jun 2024
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Hint: Exophthalmic goitre is defined as a disease which is characterised by enlargement of thyroid gland occurs, increase in basal metabolic rate, protrusion of the eyeballs and weight loss appears.
Exophthalmic goitre is also known termed as Graves’ disease or toxic diffuse goitre.

Complete answer:
The thyroid gland becomes larger in size in comparison to its normal size and also causes exophthalmos which leads to protrusion of eyes that result in double vision and sometimes loss of vision. Exophthalmic goitre is defined as an autoimmune disease of the body because antibodies are produced by our body. It takes place in young to middle age humans.

Now let us find solution from given options :
Hyposecretion of thyroxine : Hyposecretion or less secretion of thyroxine causes weight gain, hair loss, lowered body temperature, puffed skin and decrease in pulse rate of the body. This disease is termed as Myxoedema.
Hypersecretion of thyroxine : Exophthalmic goitre is defined as an endocrine disorder that occur due to excess thyroid hormone action in tissue which is known as thyrotoxicosis and also results in hyperthyroidism which means excess and more secretion of thyroid hormone or hypersecretion of thyroxine.
Hypersecretion of thyrocalcitonin : Hypersecretion or more secretion of thyrocalcitonin can lead to calcium tetany disease.
Hyposecretion of thyrocalcitonin : Calcitonin hormone is secreted by thyroid gland when there occurs an increase in blood calcium level in the body. This hormone reduction and less secretion in activity of calcitonin and number of osteoclasts which help in controlling blood calcium level of the body.

Hence, the correct answer is option (B)

Note: There is no treatment and permanent cure for the Exophthalmic goitre till now. It is treated and controlled with the help of radioactive iodine, antithyroid drug or if the situation becomes critical the thyroid is removed surgically.