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How does glucose convert to pyruvate?

Last updated date: 21st Jul 2024
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Hint: Glycolysis is the process of breakdown of glucose or similar hexose sugar into two molecules of pyruvic acid through a series of enzyme mediated reactions releasing some energy in the form of ATP and reducing power as NADH. This reaction takes place in the cytoplasm.

Complete answer:
To begin with, we must know the discoverer. It was discovered by Embden, Meyerhof and Parnas and so the process of glycolysis is also known as the EMP pathway.
It begins with breaking of glucose into glucose-6-phosphate in the presence of hexokinase and mg, which in turns get isomerized to fructose-6-phosphate in the presence of phosphate isomerase.
Now this fructose-6-phosphate gets converted into fructose-1,6-bisphosphate in the presence of phosphofructokinase, which in the presence of enzyme aldolase, splits into – 3-phosphoglyceraldehyde (3 PGAL) and dihydroxyacetone phosphate (DHAP), that are interconvertible.
In the next step, we will see phosphoglycerate kinase catalysis which is the formation of 1-3 diphosphoglycerate from 3-PGAL.
Consequently, 3-phosphoglycerate is converted into 2-phosphoglycerate and phosphoenolpyruvate (PEP). Using PEP, the enzyme pyruvate kinase catalyses the formation of pyruvate and liberates ATP.
This is a schematic diagram of conversion of glucose to pyruvic acid or pyruvate. This step by step breakdown will make the conversion even more clear to you.
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Glycolysis is the common phase of aerobic and anaerobic respiration.
It is a series of 10 biochemical reactions which occur in cytoplasm . In this process 10 enzymes are used forming 11 substrates.
The conversion of glucose to fructose 1,6 – Bisphosphate is known as phosphorylation.