Answer
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Hint:Detoxification is the process in which toxins are converted into less harmful chemicals by oxidation, reduction and hydrolysis reaction. A group of enzymes mediated in the reactions. In these reactions chemicals convert. The converted chemicals are then attached to another substance via a conjugation reaction.
Complete Answer:
$P_450$ are a group of oxygenase enzymes which are present on ER of liver cells are responsible for detoxification of a number of xenobiotics, toxin products ,and drugs of endogenous metabolism inside our body. The detoxification process is done by the smooth endoplasmic reticulum in liver cells . Liver cells contain enzymes that catalyze a number of reactions and can make lipid-soluble drugs and metabolic wastes which are soluble in water, so that these can easily be excrete out from the body .
Additional information:
Functions of endoplasmic reticulum:-
->Smooth endoplasmic reticulum is the site of protein synthesis
->It helps in transportation of intracellular and intercellular transport of materials. It transports chemicals between cells and within cells.
->SER also helps in protein synthesis.
->SER detoxifies many drugs and poisons in liver cells.
->Proteins and lipids synthesized on ER are used for making cell membranes. The process is known as membrane biogenesis.
->It provides a large surface area for various metabolic reactions.
Hence the correct answer is option ‘D’.
Note:The cytochrome $P_450$ are a group of heme-containing isoenzymes. These enzymes primarily involved in the lipid bilayer of the endoplasmic reticulum of hepatocytes, it takes part in the metabolism of many drugs, steroids and carcinogens.
Complete Answer:
$P_450$ are a group of oxygenase enzymes which are present on ER of liver cells are responsible for detoxification of a number of xenobiotics, toxin products ,and drugs of endogenous metabolism inside our body. The detoxification process is done by the smooth endoplasmic reticulum in liver cells . Liver cells contain enzymes that catalyze a number of reactions and can make lipid-soluble drugs and metabolic wastes which are soluble in water, so that these can easily be excrete out from the body .
Additional information:
Functions of endoplasmic reticulum:-
->Smooth endoplasmic reticulum is the site of protein synthesis
->It helps in transportation of intracellular and intercellular transport of materials. It transports chemicals between cells and within cells.
->SER also helps in protein synthesis.
->SER detoxifies many drugs and poisons in liver cells.
->Proteins and lipids synthesized on ER are used for making cell membranes. The process is known as membrane biogenesis.
->It provides a large surface area for various metabolic reactions.
Hence the correct answer is option ‘D’.
Note:The cytochrome $P_450$ are a group of heme-containing isoenzymes. These enzymes primarily involved in the lipid bilayer of the endoplasmic reticulum of hepatocytes, it takes part in the metabolism of many drugs, steroids and carcinogens.
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