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Decline in the activity of enzyme hexokinase by glucose 6-phosphate is caused by
A. Non – competitive inhibition
B. Competitive Inhibition
C. Allosteric Modulator
D. Denaturation of enzyme

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Last updated date: 20th Jun 2024
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Answer
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Hint: In metabolic pathways, chemicals catalyzing irreversible responses are expected destinations of control. In glycolysis, the responses catalyzed by hexokinase, phosphofructokinase, and pyruvate kinase are irreversible; henceforth, these chemicals would be relied upon to have administrative just as a catalytic role.

Complete answer:
Hexokinase is a protein that phosphorylates a six-carbon sugar, a hexose, to a hexose phosphate. In many tissues and creatures, glucose is the most significant substrate of hexokinases, and glucose 6-phosphate the most significant item.
Glucose is interesting in that it very well may be utilized to create ATP by all cells in both the presence and nonappearance of sub-atomic oxygen. The initial phase in glycolysis is the phosphorylation of glucose by hexokinase.
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By catalyzing the phosphorylation of glucose to yield glucose 6-phosphate, hexokinases keep up the declining focus inclination that favors the encouraged vehicle of glucose into cells. This response likewise starts all physiologically significant pathways of glucose use, including glycolysis and the pentose phosphate pathway. The expansion of a charged phosphate bunch at the 6-position of hexoses additionally guarantees 'catching' of glucose and 2-deoxyhexose glucose analogs (for example 2-deoxyglucose, and 2-fluoro-2-deoxyglucose) inside cells, as charged hexose phosphates can only with significant effort across the cell layer.

So, the correct answer is option C.

Note:
Hexokinase has a high proclivity for glucose, the hexokinase is allosterically hindered by its item which is glucose-6-phosphate. At the point when the centralization of glucose-6-phosphate expands, it ties with the compound at its allosteric site and achieves the conformational change in the protein. Because of this protein can no longer tie to the glucose and the forward response is restrained. Such sort of restraint is known as feedback inhibition.