Question

Best reagent for nuclear iodination of aromatic compound is

Answer 1

Hint: In the given question reagent used in nuclear iodination of aromatic compounds is discussed. A notable feature of this system is that even acid sensitive chemicals such as anilines can also be iodinated quantitatively by this system.

Complete step by step solution:
During iodination of aromatic compounds, HI is produced which is a strong reducing agent and can reduce iodobenzene back to benzene. To prevent this, oxidizing agents such as iodic acid, nitric acid or mercuric oxide are used. Some of the advantages are seen when the reagent is included such as mild condition of the reaction, no need of adding the catalyst in the reaction, short reaction time, simple practical procedure, giving excellent yield of the product.
 It can be say that \[{I_2}/{\text{ }}HN{O_3}\] act as an effective iodinating agent for a various of organic molecules and this process can be performed in an acidic medium providing a practical alternative measure to other procedures by avoiding the use of harsh reaction conditions like high temperature, long reaction time, costly metal catalyst and many more. The most preferred reagent for iodination of aromatic compounds is iodine in presence of\[\;C{H_3}CN\]because of the nature of \[\left( { - C \equiv N - } \right)\]

Thus, the Best reagent for nuclear iodination of aromatic compounds is \[{I_2}/{\text{ }}HN{O_3}\].

Note: A new reagent arrangement system has been set up which is done by involving of \[{I_2}/{\text{ }}HN{O_3}\] in Aromatic alcohol has been found to be more effective in iodinating a variety of commercially important substrates under ambient conditions. This Process leads to a high amount of yield, something 90 to 98% at room temperature within a short reaction period.