Question

Antibiotic inhibiting interaction between t-RNA and m-RNA during protein synthesis in bacteria is:
A. Tetracycline
B. Neomycin
C. Erythromycin
D. Streptomycin

Answer 1

Hint: Neomycin is a member of the aminoglycoside class of antibiotics. Neomycin, like other members of the aminoglycoside family, exerts its bactericidal effects by preventing the synthesis of bacterial proteins.

Complete step by step solution:
Antimicrobial resistance occurs when bacteria, fungi, and other microorganisms learn to resist the medications meant to kill them. That implies that the germs survive and develop. Rifampicin specifically inhibits bacterial RNA polymerase to prevent the beginning of RNA production. Because it does not interact with mammalian RNA polymerases, it is only active against some Gram-positive and some Gram-negative bacteria. It has been established that the antifungal activity's mechanism is inhibition of RNA production. These findings imply that a potential target for antifungal therapy could be the suppression of fungal RNA production. The main causes of morbidity and mortality in the immunocompromised host are invasive fungal infections.
Tetracycline prevents the addition of amino acids to the expanding polypeptide chain by interfering with the attachment of the tRNA carrying the amino acid to the mRNA-ribosome complex. By altering the structure of the 30S proton on the 70S bacterial ribosome, streptomycin prevents the first stages of protein synthesis.
Tetracyclines stop aminoacyl-tRNAs from binding to the ribosome by blocking the A site. It prevents mRNA and tRNA from interacting when translating. Erythromycin suppresses mRNA translocation during translation by binding to the 50S subunit. The 30S subunit's structure is altered when streptomycin binds to specific locations on the subunit, causing a misreading of the genetic code that results in aberrant proteins.
So, option (B) is correct.

Note:
Neomycin should not be taken if you have an allergy to it, ulcerative colitis, Crohn's disease, another inflammatory bowel illness, an intestinal blockage, or a reaction to other antibiotics such amikacin, gentamicin, kanamycin, paromomycin, streptomycin, or tobramycin.