Questions & Answers

When a cell has a stalled DNA replication fork, which checkpoint should be predominantly activated?
A. M
B. Both G, M, and M
C. \[{G_1}/S\]
D. \[{G_2}/M\]

Answer
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Hint: Stalled forks DNA replication activates checkpoint motioning and pause replication. Since the \[{G_1}/S\] checkpoint checks DNA damage, cells size previous to S-phase, that is DNA replication phase. This checkpoint would be prompted by a stalled DNA replication fork.

Complete answer:
The DNA replication stress term depicts the state of a cell whose genome is endangered by numerous stresses. The events that participate in replication stress happen during DNA replication, as well as it can result in a stalled replication fork. There are several events that provide to replication stress, including:
> Misincorporation of ribonucleotides.
> Unusual DNA configurations.
> Tensions between replication and transcription.
> Insufficiency of important replication factors.
> Common fragile sites.
> Overexpression also known as constitutive activation of oncogenes.
> Chromatin inaccessibility.
ATM along with ATR are proteins that abet to alleviate replication stress. Specifically, they are kinases that are recruited as well as activated by DNA damage. The stalled replication fork can decline if these regulatory proteins fail to solidify it. When this situation arises, reassembly of the fork is initiated in decree to overhaul the damaged DNA end.
Option - A – is not the right answer according to the question.
Option – B – is not a valid answer to this question.
Option – C – is the appropriate answer to the provided question.
Option – D – is not the correct answer to the question above.

Thus, the valid answer to the question is Option – C “\[{G_1}/S\]”

Note:
The replication fork comprises a group of proteins that affect the activity of DNA replication. In order for the replication fork to stall, the cell must retain a distinct amount of stalled forks as well as arrested length.