Question

Factors leading to an increase in the risk of thalassemia disease
A. Certain ancestry
B. Family history of thalassemia
C. Only B
D. Both A and B

Answer 1

Hint:
Before answering the question, we should know about thalassemia.
Thalassemia is a genetically transmitted (i.e., handed from parents to children) blood illness that develops when the body doesn't produce enough haemoglobin, a crucial component of red blood cells.
You can get a blood test to see if you have the thalassemia trait and are at risk of passing it on to your offspring. If your partner is known to have thalassemia or if you have a family history of the disorder, this information may be especially helpful. The majority of people with thalassemia minor or trait do not require blood transfusions since their anaemia is either absent or mild. Red blood cells can grow with the aid of folic acid.

Complete answer:
Factors that more likely to develop thalassemia if you have: Thalassemia in the family. Mutated haemoglobin genes allow thalassemia to be transferred from parents to offspring. A Hb-B gene mutation is the primary cause of most cases of beta-thalassemia. The illness is incredibly rare and is brought on by a genetic loss (deletion) that involves the Hb-B gene. Instructions for making proteins that are essential to numerous bodily processes are provided by genes.
So, the factors leading to an increase in the risk of thalassemia disease are both certain ancestry and family history of thalassemia.

Option ‘D’ is correct

Note:
The DNA of the cells that produce haemoglobin, the component of red blood cells that transports oxygen throughout the body, is mutated in thalassemia patients. Thalassemia-related mutations are transferred from parents to offspring. Incorrect genes that impact the generation of haemoglobin are the root cause of thalassemia. Thalassemia can only be passed down from one or both parents to a kid who is born with it.