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What are modified amino acids? Give Examples.

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Last updated date: 13th Jul 2024
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Answer
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Hint: Modified amino acids are created by modifying a single amino acid. Modified amino acids are in-house manufactured amino acid derivatives with unique properties that enable cell culture processes to be intensified.

Complete answer:
Modified amino acid applications
1. The use of modified amino acids can also have a beneficial effect on the length or productivity of cell culture.
2. Phospho-L-Tyrosine disodium salt and S-Sulfocysteine sodium salt can be used in conjunction to produce highly concentrated, neutral pH feeds in place of tyrosine and cysteine.
3. Because of the high feed concentration possible with changed amino acids, it is possible to reduce feed volume addition in biopharmaceutical production, which can result in an increase in titer.
Many biomolecules are polyfunctional, meaning they contain two or more distinct types of functional groups, each with its own set of chemical properties and reactions.
Amino acids are a type of polyfunctional molecule that contains at least two functional groups: an amino group and a carboxylic group. Tyrosine is an amino acid with an alcoholic group.
Tyrosine is the precursor to a family of catecholamines that includes dopamine, norepinephrine, and epinephrine.

Note:
Carboxyglutamic acid is a calcium-binding amino acid residue present in the blood-clotting protein prothrombin (as well as in other proteins that bind calcium as part of their biological function).