Question

A pregnant woman who has done amniocentesis test finds an extra Ban- body in her embryo. The syndrome which is likely to be associated with the embryo is:  
A. Edward's syndrome   
B. Down's syndrome
C. Klinefelter's syndrome                 
D. Patau's syndrome

Answer 1

Hint: There are stainable sex chromosomes and Barr bodies in the nucleus. Each X-chromosome has a Barr body. Therefore, the XX female will display one bar body, but the XY man will not display a bar body. Therefore, it will display two Barr bodies if there are XXY. So, in accordance with the question, we need to find the disorder in which there is an XXY condition.


Step by step solution:
Edward’s syndrome: It is a hereditary condition in which chromosome 18 has a trisomy. The boys' numerous organs, most notably the heart, are affected by the extra copy of the entire chromosome 18 or the portion of the chromosome that is present. The youngster may have a small skull, overlapping fingers, and clenched fists in addition to a mental handicap. It typically develops during the creation of the reproductive cells rather than being inherited from the parents.

Down’s syndrome: It is a hereditary condition in which chromosome 21 has a trisomy. The presence of the extra copy of the entire chromosome or a portion of the chromosome is what causes the body to develop physically. This condition may lead to mental impairment and a number of distinctive facial traits.

Klinefelter's syndrome: This hereditary condition is likewise brought on by the existence of an extra copy of the X chromosome, which results in an extra Barr body and a karyotype of 47, XXY. Such a person has a fully formed masculine personality. However, there is also an expression of feminine growth (breast development, or gynecomastia). They are infertile people.

Patau's syndrome: The nondisjunction of chromosomes during meiosis is what causes Patau's condition, also known as trisomy 13. Instead of the normal two copies of chromosome 13—one from the mother and one from the father—patau syndrome cells have three copies of this gene, along with additional material from the extra chromosome that is joined to another chromosome.

Hence, the correct option is C. Klinefelter's syndrome


Note: A genetic process, such as mendelian genes, multi-factor genes, chromosomal aberrations, or anomalies, can result in problems known as genetic diseases. Chromosome disorders are hereditary diseases brought on by chromosomal aberrations and abnormalities. Dysfunctional synapsis and disjunction during meiosis cause chromosomal abnormalities to arise.