Question

Write down the causes of histamine?

Answer 1

Hint: An allergy is an immunological hypersensitivity reaction that is mediated by immunoglobulin E antibody. Histamine is a compound that is released by mast cells and basophils in response to injury and in allergic and inflammatory reactions which causes contraction of smooth muscle and dilation of capillaries.

Complete Answer:
The main causes of histamine release are:
Headaches
Migraines
Sinusitis
Fatigue
Digestive problem
Irregular menstrual cycle
Vomiting
Histamine is a potent vasodilator. The histamine serves a wide variety of functions. It helps in the contraction of smooth muscles in the bronchi and gut and also helps in relaxation of muscles in the walls of fine blood vessels. Nasal congestion due to common cold and allergic response to pollen are due to histamine secretion. The permeability of WBC increased by histamine and this allows the pathogens to get engaged with the infected tissues. Histamine can act as a neurotransmitter also.

Additional Information:
Antihistamine is a class of drugs that prevent the physiological action of histamines. When our body comes in contact with antigens such as pollen, dust mites, pet dander etc, a chemical called histamine is released that triggers an allergy which causes swelling of the nose, running eyes. So basically, antihistamines block the action of histamines and protect us from the symptoms of different kinds of allergy. They interfere with the natural action of histamines where they compete with the histamines in order to obtain the binding sites of the receptor, where histamines exert their effect.

Notes:
Antihistamines are basically divided into two.
First generation antihistamines and Second-generation antihistamine.
Second generation antihistamine does not cause the sedation and drying seen in first-generation antihistamines.