Question

Which among the following conditions is necessary for a cell to qualify through the G2 checkpoint?
A. Complete and accurate DNA replication
B. Cell should be of a size sufficient enough
C. Complete attachment of mitotic spindle fibers to kinetochores
D. Sufficient stockpile of nucleotides

Answer 1

Hint:
A checkpoint is a point in the eukaryotic cell cycle at which the cell examines internal and external signals and decides whether or not to continue with division. The three most crucial ones are the G1 checkpoint, on the G1/S transition, the G2 checkpoint, at the G2/M transition, and the spindle checkpoint, at the transition from metaphase to anaphase.

Complete step by step answer:
To make sure that cellular division is producing healthy daughter cells with complete, undamaged DNA, the cell has an extra checkpoint before the M phase. At this level, the cell will check DNA integrity, where it checks if any of the DNA is damaged, and DNA replication, where it checks if the DNA is completely copied at some stage in the S phase.
If errors or damages are detected, the cell will pause at the checkpoint to allow for repairs. If the checkpoint mechanisms identify errors in the DNA, halting of the cell cycle occurs, and the cell tries to repair the DNA damage or finish DNA replication. If the damage is irreparable, the cell can also go through apoptosis, or programmed cell death.
In metaphase complete attachment of mitotic spindle fibers to kinetochores can be seen. During the interphase, the cell should be of a size sufficient to undergo cell division and a sufficient stockpile of nucleotides occurs.

Option ‘A’ is correct

Note:
The uncontrolled division of the cells results in cancer. The self-destruction mechanism guarantees that damaged DNA isn't passed directly to daughter cells and is essential in preventing most cancers.