
Where are T cells derived from?
Answer
494.7k+ views
Hint: T lymphocytes (also known as T cells) are important components of the adaptive immune system. They are named after the thymus, which is responsible for their development. It plays a direct role in the destruction of infected host cells, the production of cytokines, the activation of other immune cells, and the regulation of the immune response.
Complete answer:
T cells are produced in the bone marrow from hematopoietic stem cells. Few multipotent cells become progenitor cells, which leave the bone marrow and travel through the blood to the thymus. The thymus is where these cells mature.
T cells in the thymus go through a selection process in which the majority of developing T cells (known as thymocytes) fail to pass and thus die. Those Thymocytes that pass, interact with self-MHC molecules and accept positive signals survive, while Thymocytes with receptors receive negative signals and are eliminated (those with self-antigenic properties).
T cells then develop their antigen-specific T cell receptor (TCR). T cells that make it through thymic selection mature and leave the thymus. They then pass through the peripheral lymphoid structures, where they are stimulated and take up a specific antigen. T cells grow and differentiate into effector T cells after being activated.
The thymus involutes as we age, and we produce fewer naive T cells as a result. This is equivalent to saying that as people get older, their T cell diversity decreases, increasing their susceptibility to infections.
Thus, T cells are derived from Bone marrow.
Note:
The main function of these T cells is to provide memory to the immune system against previously encountered antigens. CD8+ or CD4+ cells can be found in these cells. Memory T cells form whenever there is an infection. These cells have a long lifespan and are antigen-specific. These cells are important because they can quickly expand to a large number of effector T cells when exposed to the virus in the future.
Complete answer:
T cells are produced in the bone marrow from hematopoietic stem cells. Few multipotent cells become progenitor cells, which leave the bone marrow and travel through the blood to the thymus. The thymus is where these cells mature.
T cells in the thymus go through a selection process in which the majority of developing T cells (known as thymocytes) fail to pass and thus die. Those Thymocytes that pass, interact with self-MHC molecules and accept positive signals survive, while Thymocytes with receptors receive negative signals and are eliminated (those with self-antigenic properties).
T cells then develop their antigen-specific T cell receptor (TCR). T cells that make it through thymic selection mature and leave the thymus. They then pass through the peripheral lymphoid structures, where they are stimulated and take up a specific antigen. T cells grow and differentiate into effector T cells after being activated.
The thymus involutes as we age, and we produce fewer naive T cells as a result. This is equivalent to saying that as people get older, their T cell diversity decreases, increasing their susceptibility to infections.
Thus, T cells are derived from Bone marrow.
Note:
The main function of these T cells is to provide memory to the immune system against previously encountered antigens. CD8+ or CD4+ cells can be found in these cells. Memory T cells form whenever there is an infection. These cells have a long lifespan and are antigen-specific. These cells are important because they can quickly expand to a large number of effector T cells when exposed to the virus in the future.
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