Question

Types of antibodies involved in asthma are?
A) IgA                                         
B) IgM
C) IgE             
D) IgD         

Answer 1

Hint: In mammals, there are five classes or isotypes of antibodies or immunoglobulins, IgA, IgD, IgE, IgG, IgG, and IgM, each with its class of heavy chain. Asthma is an output of a hypersensitive reaction occurring in our body. It is an exaggerated response in tissue and is manifested in the individual on second or subsequent contact with the antigen.


Complete step-by-step answer:

 IgE mediates the immediate hypersensitivity reactions that are responsible for the symptoms of hay fever, asthma, hives, and anaphylactic shock. Cross-linkage of receptor-bound IgE molecules by antigen(allergen) induces degranulation of basophils and mast cells; as result, a variety of pharmacologically active mediators give rise to allergic manifestations.
IgA is the major immunoglobulin found in the colostrums of milk in nursing mothers, and It may provide the neonate with a major source of protection against pathogens during the first few weeks after birth.
IgM is the first antibody class produced in the primary response to an antigen, and it Is also the first antibody to be synthesized by the neonate. IgM is more efficient than IgG in activating complement. Complement activation requires two Fc regions near and IgM fulfills that.
IgD: No effector function has been identified for IgD.


Therefore the correct answer is Option C.
Note: Type I hypersensitivity (also known as an allergic reaction) is induced by antigens referred to as allergens. Type I hypersensitive reactions are Ig-E mediated humoral antibody responses. These IgE-mediated reactions are stimulated by the binding of IgE to high-affinity IgE-specific Fc receptors expressed on mast cells and basophils.