Question

TPP means
a)Thiamine pyrophosphate
b)Thymine pyrophosphate
c)Thymine Penta phosphate
d)none of the above

Answer 1

Hint: TPP is a derivative of the enzyme thiamine diphosphokinase. It is an active form of thiamine and it also functions as a coenzyme for other enzymes. It is helpful in the carbohydrate metabolism. It is present in the form of vitamin B1.

Complete answer: TPP is the full form of the thiamine pyrophosphate. It is also known as thiamine diphosphate. It is a derivative of thiamine or vitamin B1. It helps in the metabolism of the carbohydrate and amino acids by stabilizing the acyl carbanion bio synthons. It is a cofactor for various enzymes like transketolase, pyruvate dehydrogenase, and alpha-ketoglutarate dehydrogenase. It is also involved in the oxidative decarboxylation of pyruvate and amino acids. Thiamine is utilized by the cell in its active form which is TPP and is formed from TPK (thiamine pyrophosphokinase). The TPP form of thiamine is transported from the cytosol of the cell to the mitochondria for its proper utilization. Thiamine is a water-soluble compound that can cause various deficiency syndromes in many people. The person who is on dialysis is more prone to the deficiency of the thiamine and can have an effect on their health. TPP is absent in the plasma of the blood and is also absent from the cerebrospinal fluid.

So, the answer is ‘thiamine pyrophosphate’.

Note: If there are any defects in the TPP transporter then it can lead to encephalopathy or can also lead to paralysis in some people and children. The deficiency of this enzyme leads to beriberi when depletion of food occurs. Prolonged fasting also causes the deficiency of the thiamine leading to the neurological symptoms.