Question

The statement which is incorrect with respect to enzyme action is:
A. Addition of a lot of succinate does not reverse the inhibition of succinic dehydrogenase by malonate
B. The substrate binds with the enzyme at its active site
C. A non-competitive inhibitor binds the enzyme at a site distinct from that which binds the substrate
D. Malonate is a competitive inhibitor of succinic dehydrogenase

Answer 1

Hint:
Before we proceed into the problem, it is important to know the definition of the enzyme.
The enzyme is a protein that helps in the chemical reaction that occurs during digestion. Depending on the type of enzyme, it can be responsible for breaking down complex molecules into their constituent parts or aiding in the transport of nutrients from one cell to another.

Complete step by step answer:
Succinic dehydrogenase is competitively inhibited by malonate. Malonate ions, which resemble succinate ions in the form very much, block the process. Therefore, the active site is blocked by the malonate ions, but this is reversible. The enzyme will once more become free of the malonate ions. At the enzyme's active site, the substrate binds.
An enzyme is bound by a non-competitive inhibitor at a location other than the active site, which is the location where the substrate is bound. As a result, it has no impact on the concentration of the substrate. The addition of more substrate will not reverse this kind of inhibition.
The enzyme's active site, which is also where the substrate is bound, is where a competitive inhibitor attaches. The addition of more substrate can reverse this kind of inhibition.
Therefore, the addition of a lot of succinate does not reverse the inhibition of succinic dehydrogenase by malonate is an incorrect statement.

Option ‘A’ is correct

Note:
For instance, succinic dehydrogenase is competitively inhibited by malonate. Malonate and succinate bind to the succinic dehydrogenase enzyme's identical active site. The malonate-induced inhibition of succinic dehydrogenase can be reversed by adding a lot of succinate.