Question

The First Clinical Gene Therapy was given for treating
A. Diabetes Mellitus
B. Chicken Pox
C. Rheumatoid Arthritis
D. Adenosine deaminase deficiency

Answer 1

Hint: Gene Therapy is an assortment of technology that enables correction of cistron defects diagnosed in an exceedingly kid or embryo. Here genes are inserted into individual cells or tissue to treat illness. French Anderson is known as the Father Of Gene Therapy.

Complete answer:
The expression of ADA protein is found all over within the atmosphere, and it’s survival additionally has several benefits. Whereas different {the opposite} organic phenomenon of other illnesses like Chicken Pox, diabetes and atrophic arthritis isn't found simply.

Hence, option (D) (Adenosine Deaminase deficiency) is the correct answer.

Additional Information: Gene Therapy is the process by which a hereditary disease can also be cured. Correction of a genetic defect involves the delivery of a normal gene into an individual or embryo over the defective gene. The first Clinical Gene therapy was given in 1990 to a 4-year-old girl with adenosine deaminase deficiency(ADA). This enzyme is important for the immune system to function. The disease is caused due to deletion of the gene for Adenosine Deaminase. To cure this disease either the bone marrow is replaced or by replacing the gene i.e by gene therapy.Ge

The Gene Therapy Method works as:-
I. The white blood cells or the lymphocytes are taken from the blood of the patient and then it’s cultured in a medium outside the body.
II. A functional ADA gene is then introduced into the lymphocytes by using a retroviral vector.
III. These lymphocytes are then injected back into the blood of the patient.
These cells i.e the white blood cells or the lymphocytes are generally immortal. However, the patient requires Periodic infusion of such genetically engineered Lymphocytes. But if the gene is isolated from the bone marrow cells producing ADA enzymes then it’s a permanent cure.

Note: The recombinant DNA technological processes have made an intense impact in the area of health care by introducing safe and effective drugs and technologies. Such one technology is Gene Therapy. Genetic Therapy has the potential to cure numerous genotypic diseases and that the procedures appear to have minimal risks to the patient.