Question

Synaptic fatigue is due to
A) Exhaustion of neurotransmitter
B) Release of more acetylcholine
C) Release of more adrenaline
D) None of the above

Answer 1

Hint: Synaptic fatigue occurs when the excitatory synapses are stimulated repetitively at a higher rate, then the amount of discharge gradually reduces.

Complete answer:
Let us analyse the options and find the correct answer.

->Option A: When a neurotransmitter is exhausted it leads changes in the energy levels. But it has nothing to do with synaptic fatigue. Therefore, this is the incorrect option.
->Option B: When acetylcholine is released in excess it leads to synaptic fatigue. Synaptic fatigue occurs when there is a drastic decrease in the postsynaptic response. Therefore, this is the correct option.
->Option C: When there is excess of adrenaline it is known as adrenaline rush. It increases the blood flow between the brain and the muscles. But it has nothing to do with synaptic fatigue. Therefore, this is the incorrect option.
->Option D: As one of the answers is correct, this is the incorrect option.

Thus, the correct option is option (B) Excess of acetylcholine.

Note:Acetylcholine is a neurotransmitter which are released from motor neurons.The cells which release acetylcholine are known as cholinergic neurons They help in,
->They trigger muscle contraction
->They have an inhibitory effect on cardiac muscles
->They have an excitatory effect on skeletal muscles
->Their level decreases in the brain during Alzheimer’s