Question

Sulpha drugs act as competitive inhibitors
A. In folic acid synthesis in bacteria
B. In folic acid synthesis in viruses
C. For succinate dehydrogenase
D. For glucose 6-phosphate

Answer 1

Hint: These drugs are a group of medications which is to treat the bacterial infections and it acts as competitive inhibitors to inhibit the growth where it is present.

Complete answer:
First of all, you should know that Sulpha drugs are a group of medicines to treat bacterial infections and they may be prescribed to treat some diseases like urinary tract infections, bronchitis, eye infections, pneumonia, ear infections, burns, traveller's diarrhea and some other conditions too.

Folic acid is used in synthesis of the nucleic acid. For the synthesis of folic acid in bacteria Dihydropteridine and p-aminobenzoic acid reactions in the presence of enzymes for their synthesis. There the Sulpha drugs act as a competitive inhibitor and it gets attached to the active site of the enzyme and then it inhibits the growth and multiplication of bacteria by inhibiting the formation of folic acid.

> So, if we look at option D which is For glucose 6-phosphate. This option is incorrect as it acts as competitive inhibitors in bacteria in folic acid synthesis. So, this option is incorrect.

> Moving to option C which is For succinate dehydrogenase. This is also incorrect as it does not act as competitive inhibitors for this enzyme.

> Moving to option B which is In folic acid synthesis in viruses. Sulpha drugs act as competitive inhibitors in folic acid synthesis but not in viruses but in bacteria as sulpha drugs are used to treat bacterial infections.

> The last option is A which is In folic acid synthesis in bacteria. This one is correct as Sulpha drugs act as competitive inhibitors in folic acid synthesis in bacteria.

Hence, The correct answer is option (A).

Note: These drugs act as competitive inhibitors in the folic acid in bacteria, there it gets attached to the active site of the enzyme and starts to inhibit the formation of folic acid and thus, it inhibits the growth and multiplication of the bacteria.