Question

In how many steps, glycolysis can be regulated?
A. One
B. Two
C. Three
D. Four

Answer 1

Hint: Glycolysis is a cytoplasmic pathway which breaks down glucose and generates energy into two three-carbon compounds. For energy generation, glycolysis is used by all cells in the body. Pyruvate in aerobic settings and lactate in anaerobic environments are the final result of glycolysis. For more energy output, Pyruvate joins the Krebs cycle.

Complete answer:
It is a general metabolic regulation rule that, at the first committed stage, pathways are regulated. The step taken is the one after which there is only one path for the substrate to go. The control of glycolysis happens at more than one stage because glycolytic intermediates feed into many other pathways. This enables it to regulate the regulation of many pathways. For triglyceride formation, glycerol is required, even though ATP synthesis is less important. Metabolic control must therefore allow glucose to be transformed into triose even though the complete breakdown of the trioses to CO 2 need not occur at such a high rate. The free energy difference between products and reactants in the normal state and the concentration of products and reactants depends on two factors: the free energy difference between products and reactants.
For different cellular metabolic processes, glycolysis is the process of breakdown of glucose into pyruvate to extract energy. The regulatory steps for allosteric enzyme regulation are enzymes that catalyse the three steps of glycolysis with a very high negative G value, hexokinase (or glucokinase) for step 1, phosphofructokinase for step 3, and pyruvate kinase for step 10.

Hence, the correct answer is (c) Three

Note: In general, enzymes that catalyse irreversible steps in the metabolic pathway have the capacity for regulatory control since a pathway that leads to the accumulation of intermediates is rather blocked elsewhere. The genetics of human glycolysis are complicated by the presence of isoenzymes specific to the tissue and cell type and because several glycolytic enzymes and their genes have extra functions beyond a strictly catalytic role.