Question

What will happen if the secretion of parietal cells of gastric glands is blocked with an inhibitor?
A)In the absence of HCl secretion, inactive pepsinogen is not converted into the active enzyme pepsin.
B)Enterokinase will not be released from the duodenal mucosa and so trypsinogen is not converted to trypsin
C)Gastric juice will be deficient in chymosin
D)Gastric juice will be deficient in pepsinogen

Answer 1

Hint: The many cells present in the stomach involve gastric secretions which are parietal cells, chief cells, D-cells, mucous cells, etc. Water, electrolytes, hydrochloric acid, and glycoproteins all are secreted by the stomach. Gastric acid is necessary for protein digestion. It also plays a role in the prevention of bacterial overgrowth and enteric infections.

Complete answer:
The microscopic tubular glands which are formed by the epithelial cells of the stomach are known as gastric glands. The parietal cells present in a large number on the sidewalls of the gastric glands.
-The parietal cells secrete hydrochloric acid and also secrete intrinsic factors which help in maintaining a strong pH of the stomach (about 1.5-2.0).
-The pepsinogen is converted to pepsin and prorenin converted to renin by hydrochloric acid.
-If the parietal cell secretion is blocked with an inhibitor then the Pepsinogen is not able to convert into the active pepsin.
-Therefore, in the absence of hydrochloric acid, the inactive pepsinogen is not able to convert into active enzyme pepsin.

Additional Information: -The three types of gastric glands are present which are different from each other by their locations and their type of secretion.
-At the very beginning of the stomach the Kadi gastric glands are located, in the central stomach areas, the intermediate or the true gastric glands are located and in the terminal stomach portions, the pyloric gland located.
-Mucus is secreted by both cardiac and pyloric glands. The mucus covers the stomach and protects it from self-digestion by helping to dilute acid and enzymes.

So, the correct answer is, "In the absence of HCl secretion, inactive pepsinogen is not converted into the active enzyme pepsin".

Note: The epithelial cells in the stomach which secretes hydrochloric acid and intrinsic factors are the parietal cells.
-The parietal cells are present in the gastric glands which are generally found in the lining of the cardia regions of the stomach.
-It also contains a secretory network of canaliculi, through which HCL is secreted by active transport into the stomach.