Question

What will happen if secretions of parietal cells of gastric glands are blocked?
A. Gastric juice is deficient of pepsinogen
B. Gastric juice is deficient of chymosin
C. Deficiency of HCl leads to non conversion of inactive pepsinogen into active pepsin
D. Nonrelease of enterokinase from duodenal mucosa and no-conversion of trypsinogen into trypsin

Answer 1

Hint: A gland is an organ which produces and releases substances that perform a specific function in the body. There are two types of glands-
1. Endocrine glands – These glands secrete their secretions directly into the bloodstream.
2. Exocrine glands – These glands secrete their secretions into the ducts.

Complete Answer:
- The gastric glands are located in the different parts of the stomach.
- These glands are also called the fundic glands, cardiac glands or pyloric glands.
- These glands are located into the stomach lining.
- The parietal cells of the gastric glands secrete Hydrochloric HCl acid.
- Hydrochloric acid is the main component of the gastric acid.
- In the presence of the HCl the proenzyme pepsinogen gets converted into the active enzyme pepsin.
- And the enzyme pepsin helps in the digestion of proteins into the stomach.
- If the secretion of parietal cells of gastric glands i.e. HCl is blocked then pepsinogen can’t be converted into the active enzyme pepsin.
- Due to which proteins will not be hydrolysed.

Hence, option C is the correct option for this question.

Note: Pepsin is an enzyme that is found in the stomach which helps in the digestion of the protein molecules found in ingested food. A low pH i.e. 1.5 – 2 is required for the activation of enzyme pepsin. It is an endopeptidase. It hydrolyses the proteins into proteoses and peptones.