Question

Give diagrammatic representation to show a perfect pairing and any two wobble pairing.

Answer 1

Hint: Genetic code is the sequence of nucleotides in mRNA that contain information for protein synthesis.The genetic code is non ambiguous. The codon is a triplet; three nitrogen base sequences constitute one codon.

Complete answer:
The degeneration of genetic course occurs because 61 codons are available for 20 amino acids. Cricks proposed a wobble hypothesis to explain the phenomenon. This hypothesis explains that in the pairing of codon and anticodon the third base pair would not be complementary. The third base of codon is called wobble base and this position is called wobble position. In only the first two positions the actual base pairing occurs. For example GUU,GUC,GUAand GUG code for amino acid valine.

Wobble hypothesis:
When a single amino acid is degenerate many codons may be specified it is because of the last base in the codon. Wobble base is also called last base. Hence the first codon is important to determine the amino acid and the third one is different which does not affect the coding. This process is called the wobble hypothesis.

Note: In wobble base pairing the pairing of the third base varies according to the base at this position. The conventional pairing is called Watson- crick pairing and the second abnormal pairing is called wobble pairing.