Question

What causes itai itai (ouch-ouch) disease ?

Answer 1

Hint: The affected locals coined the word itai-itai disease (hurts-it-hurts disease" or "ouch-ouch disease") to describe the extreme pains that people with itai-itai disease experienced in the spine and joints. In Japanese, itai is an adjective that means "painful" or an interjection that means "ouch."

Complete answer:
Cadmium (Cd) contamination, which is created as a result of human activities linked to industrialisation, causes itai-itai disease, which was first recognised in Japan in the 1960s. Osteomalacia with extreme bone pain is a symptom of Itai-itai disease, which is linked to renal tubular dysfunction.
Also, Cadmium (Cd) poisoning can result in bone softening and kidney failure. Chelators, which facilitate Cd excretion through the urine, are one of the most effective therapies. Mining companies in the mountains released cadmium into rivers, and they were successfully sued for the damage.
Water may also introduce cadmium into the food chain. Cadmium contamination of local water sources was caused by zinc mining activities in Japan. Farmers in the area used the water to irrigate their crops. The soil becomes polluted with cadmium, causing cadmium to be absorbed into their rice.

Note:
Vitamins A, C, E, and selenium, for example, may avoid or mitigate many of cadmium's harmful effects on organs and tissues including the liver, kidney, skeleton, and blood. Zinc and magnesium are the other ingredients, both of which have numerous clinical applications.