Question

Which one of the following pairs is correctly matched?
A. Vitamin-B2- Pernicious anemia
B. Vitamin B6- Loss of appetite
C. Vitamin-B1- Beri- Beri
D. Vitamin-B12- Pellagra

Answer 1

Hint: A vitamin is an organic molecule that is an essential micronutrient which an organism needs in small quantities for the proper functioning of its metabolism. Vitamin B complex is the building blocks of a healthy body. B vitamins have a direct impact on our energy levels, brain function, and cell metabolism.

Complete answer: A severe and chronic form of Vitamin B1 is known as beriberi. There are two main types of Beri-Beri in adults; wet beriberi, and dry beriberi.
Wet beriberi affects the cardiovascular system resulting in a faster heart rate, shortness of breath, and leg swelling. Dry beriberi affects the nervous system resulting in numbness of the hands and feet, confusion, trouble moving the legs, and pain. A form with loss of appetite and constipation may also occur. Another type, acute beriberi, is found mostly in babies and presents with loss of appetite, vomiting, lactic acidosis, changes in heart rate, and enlargement of the heart.
a) Riboflavin(B2) deficiency (also called ariboflavinosis) results in stomatitis including painful red tongue with a sore throat, chapped and fissured lips (cheilosis), and inflammation of the corners of the mouth (angular stomatitis).
b)Pernicious anaemia is a type of vitamin B12 deficiency disease. The body needs vitamin B12 to make red blood cells. It is caused by an autoimmune process that makes a person unable to produce a substance in the stomach called intrinsic factor(in-TRIN-sik). This substance is needed to absorb dietary vitamin B12 in the small intestine.
c) Vitamin B6 deficiency is usually caused by pyridoxine-inactivating drugs (eg, isoniazid), protein-energy undernutrition, malabsorption, alcoholism, or excessive loss. The deficiency of Vitamin B6 can cause peripheral neuropathy, seborrheic dermatitis, glossitis, and cheilosis, and, in adults, depression, confusion, and seizures. Pellagra is caused by having too little niacin (B3) or tryptophan in the diet.
So, the correct answer is option C.

Note: Due to interference with iron absorption, even mild to moderate riboflavin deficiency results in an anaemia with normal cell size and normal haemoglobin content (i.e. normochromic normocytic anaemia). This is distinct from anaemia caused by a deficiency of folic acid (B9) or cyanocobalamin (B12), which causes anaemia with large blood cells (megaloblastic anaemia). Deficiency of riboflavin during pregnancy can result in birth defects including congenital heart defects and limb deformities. Prolonged riboflavin insufficiency is also known to cause degeneration of the liver and nervous system.