Question

Which of the following statements are incorrect?

(i) Antigen-binding site of an antibody is found between two light peptide chains.

(ii) The pathogen of elephantiasis is transmitted to a healthy person through the bite of the same mosquito species which also causes malarial disease.

(iii) Lymphoid tissues are also located within the lining of the major tracts called mucosal-associated lymphoid tissue.

(iv) Increase intake of coffee or tea can cause indigestion, insomnia, and disturb renal functions.

(v) Anaphylactic shock is an autoimmune reaction that involves all the tissues of the body resulting in a drastic fall in blood pressure.

A. (i), (iii) and (v)
B. (ii) and (iv)
C. (i), (ii) and (v)
D. (i), (ii) and (iv)

Answer 1

Hint: Lymphatic filariasis, commonly referred to as elephantiasis, is a neglected tropical disease. Antigen binding takes place in the N-terminus of the variable area of both heavy and light chains and the Fab fragment includes both these regions. Anaphylactic shock is an uncommon but serious allergic reaction that can be fatal if they don't handle it right away.

Complete step-by-step answer:

 Lymphatic filariasis, widely known as elephantiasis, is a painful and deeply scarring disease. It is due to infection with parasites ranked as the nematodes (roundworms) of the family Filariodidea that are transmitted by bites of infected mosquitos. Infection is commonly acquired in childhood that causes hidden damage to the lymphatic system.
Antibodies, also called immunoglobulins, are Y-shaped polypeptide structures consisting of two light chains and two heavy chains. Antibody molecules can conduct their twin roles of antigen binding and biological activity mediation due to their structure. The amino acid series of the "Y-shaped" tips varies extraordinarily amongst antibodies. The antibody's specificity for binding antigen is specified by this variable area, which has 110-130 amino. The endpoints of the heavy and light chains are included in the variable area. Therefore, the antigen-binding site in an antibody is observed among variable regions of heavy and light chains.
Anaphylactic shock is a complication of anaphylaxis that happens when the blood pressure falls very low, and the blood has trouble circulating.

Therefore the correct answer is Option C.
Note: The thymus and bone marrow are the main lymphoid tissues and locations of lymphocyte development. The lymph nodes, tonsils, spleen, and Peyer's patches are examples of secondary lymphoid tissue. Chronic inflammation may result in the development of tertiary lymphoid tissue. Remarkably high daily consumption of 1,000 mg or more per day was reported in order to induce jitteriness, nervousness, as well as similar symptoms in most people, although even medium intake may result in similar effects in caffeine-sensitive individuals.