Question

What do Sertoli cells produce?

Answer 1

Hint: The major endocrine hormone that controls Sertoli cell function is FSH. Sertoli cells are the only cells in the testes that express FSH receptors, and Sertoli cell growth requires a combination of FSH and other hormones. Sertoli cells secrete a variety of proteins and hormones, including androgen-binding protein and anti-Müllerian hormone.

Complete answer:
Sertoli cells, also known as nurse cells, are found in the seminiferous tubules and feed male germ cells. They regulate spermatogenesis and release a variety of proteins and hormones. Androgen binding protein, inhibin, transferrin, and other proteins are secreted by them. Enzymes that convert testosterone to oestrogen are also secreted by them.

Sertoli cells are incapable of producing sperm. They are the seminiferous tubules' nutritive cells. They keep germ cells alive by supplying them with nutrients. Sertoli cells also make testicular fluid, which contains a protein that binds to and concentrates testosterone, which is necessary for spermatozoa production.

Sertoli cells are involved in the formation of the blood-testis barrier and in sperm generation. These cells respond to the hypothalamic hormone follicle-stimulating hormone (FSH), which aids in spermatogenesis.

Sertoli cells are somatic cells in the testis that are required for spermatogenesis and testis development. Sertoli cells help germ cells become spermatozoa by facilitating direct interaction and managing the environment within the seminiferous tubules.

Note: In pigs, suppressing aromatase activity with the enzyme inhibitor letrozole for as little as 1 to 12 weeks results in a 25% increase in Sertoli cells in the post-pubertal testis, as well as a corresponding rise in sperm production. Testosterone drives spermatogenesis, or the process of sperm production in the testes, which is responsible for secondary sexual characteristics that develop in males during adolescence.