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This statement about enzymes is true.
A. enzymes accelerate reactions by lowering the activation energy
B. enzymes are proteins whose three-dimensional form is key to their function
C. enzymes do not alter the overall change in free energy for a reaction
D. all of these

Answer
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Hint:
Enzymes are proteins that catalyze biochemical reactions in the body. They are essential for breaking down food and can be found in various parts of the body, including the intestines, liver, pancreas, and muscles.
While all enzymes have some degree of potential benefit when it comes to health, there are a few that may be more beneficial than others. Some of the most well-known include proteases (which break down proteins), amylases (which break down carbohydrates), lipases (which break down fats), and cellulases (which help with cell wall digestion).
Enzymes also play an important role in maintaining overall digestive function by helping to absorb nutrients from food and eliminate waste products from cells.

Complete answer:
The globular proteins that makeup enzymes have a three-dimensional structure. They decrease the activation energy to quicken the reaction while maintaining the overall change in free energy needed for the reaction. So, the statement about enzymes and their function is true for all of the above. Therefore, each of these answers is valid.

Option ‘D’ is correct

Note:
Proteins called enzymes are used by the body to catalyze chemical processes.
Enzymes are essential for all known types of life on Earth to survive. Because they are necessary for converting food into molecules that the cells can utilize, enzymes are a necessity for life. Depending on the precise task at hand, enzyme activity varies drastically between species and even within a single species. For instance, liver enzymes metabolize cholesterol while skin enzyme activity mostly contributes to the creation of collagen.