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The vaccination against smallpox means the introduction of
A. Weakened germs
B. Lymphocytes
C. Leucocytes
D. Antibodies

Answer
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Hint: Vaccination can be defined as the administration of a weakened, live or killed microorganism or virus, or proteins or toxins from the organism to boost the immune system of the human body to protect from disease.

Complete answer: The smallpox vaccine was first introduced by Edward Jenner in 1976.
1. This smallpox vaccine helps an individual to develop immunity in their body against small poxviruses.
2. A less harmful pox virus, known as vaccinia, is taken into consideration for making the vaccine of smallpox.
3. The vaccine contains a live vaccinia virus. Killed or weakened virus is not taken into consideration.
4. The vaccine cannot contain the smallpox viruses thus it will not affect a vaccinated person by smallpox.
5. In the research of Edward Jenner, milkmaids that previously had caught cowpox did not catch smallpox and showed that immunized vaccinia protected against vaccinated variola virus.
6. The vaccine is given into the arm and the individual who is taking the vaccine needs to take extra care for his hand as the excess movement of the hand can cause the spreading of the virus inside the body.

So, here the correct answer is option A. weakened germs.

Note: A smallpox vaccine can protect a person up to 3-5 years. After that, the potentiality of the vaccine decreases. If a person gets affected by smallpox before vaccination, the body itself activates its immune system and fights against the virus and keeps some memory cells for the future. If that person is again affected by smallpox, then the memory cells activate and boost the immune system to fight against the body.