Question

The average molecular mass of drugs is approximately.
A.160 – 480 g/mol
B.1600 – 4800 g/mol
C.10 – 100 g/mol
D.0.1 – 100 g/mol

Answer 1

Hint: Lipinski’s rule of five are: a molecule with a molecular mass less than 500 Da, no more than 5 hydrogen bond donors, no more than 10 hydrogen bond acceptors, and an octanol–water partition coefficient log P not greater than 5.

Complete step by step answer:
A drug is a medicine or other substance that has a psychological effect when ingested or otherwise introduced in the body.
The fastest method for the evaluation of drug-like properties of a compound is to apply the ‘rules’, which are a set of guidelines for the structural properties of compounds that have a higher probability of being well absorbed after oral dosing.
The most well-known of various guidelines was the Lipinski Rule of Five.
Lipinski rule of 5 helps us to distinguish between drug like and non-drug like molecules. It predicts high probability of success or failure due to drug likeness for molecules complying with 2 or more of the following rules:
a)Molecular mass less than 500 Dalton
b)High lipophilicity (expressed as logP less than 5)
c)Less than 5 hydrogen bond (H-bond) donors (sum of NH and \[ - OH\] )
d)Less than 10 hydrogen bond (H-bond) acceptors (sum of N and O)
e)Molar refractivity should be between 40-130
So, the average molecular mass of drugs is approximately 160 – 480 g/mol.

Therefore, the correct answer is option (A).

Note: Since the publication of Lipinski's rule of five in 1997, it has been a critical filter for drug development programs. A simple algorithm that helps identify successful drug candidates, the principles filter out molecules likely to have poor intestinal permeability or poor aqueous solubility and hence poor oral absorption.