Question

Synthesis of testosterone by Leydig cells is regulated by
A.FSH
B.TSH
C.LTH
D.ICSH

Answer 1

Hint:Testosterone is a hormone which is produced in the body which is found in male reproductive organs. It affects one's appearance and also in sexual development. It plays an important role in the production of sperm.

Complete answer:
Leydig cells, otherwise called interstitial cells of Leydig, are discovered contiguous the seminiferous tubules in the testicle. Leydig cells have polyhedral shape, and have an enormous noticeable nucleus, an eosinophilic cytoplasm and various lipid-filled vesicles. Leydig cells discharge a class of hormones called androgens. They secrete testosterone, androstenedione, and dehydroepiandrosterone, when invigorated by the luteinizing hormone (LH) which is delivered from the front pituitary in light of gonadotropin delivering hormone which in is delivered by the hypothalamus. LH ties to its receptor (LHCGR) which is a G-protein coupled receptor and thus expands the creation of cAMP. cAMP, thus through protein kinase activation, animates cholesterol movement from intracellular sources to the mitochondria. This is trailed by pregnenolone arrangement from the moved cholesterol by means of the cholesterol side-chain cleavage protein which is found in the internal mitochondrial layer, inevitably prompting testosterone to synthesis and emission by Leydig cells.

Leydig cells are the interstitial cells which are situated just adjacent to the seminiferous tubules in the testes. The main function of leydig cells is to secrete testosterone and helps in the process of spermatogenesis. These leydig cells are also found in female ovaries and sometimes may lead to cancer. They are important for the development of the reproductive tract and for the reproductive function in the males.

Foetal Leydig cells make good amounts of androgen testosterone or androstenedione, by depending upon the species essential for differentiation of male genitalia and brain masculinization.So, the correct answer for this question is option D.ICSH is interstitial cell stimulating hormone.

Hence the correct answer is option ‘D’.

Note:ICSH (Interstitial cell animating hormone) is produced by pituitary and invigorates the Leydig cells of testicles to produce testosterone. It is male sex hormone that invigorates the progression of secondary sex organs and sexual characters. Moreover invigorates spermatogenesis for example creation of sperms from the germ cells.