Question

Somatostatin is produced by _________ cells of pancreas
(a) alpha
(b) beta
(c) delta
(d) acinar

Answer 1

Hint: Cells present in islets of Langerhans of the pancreas secretes insulin and glucagon also secretes a hormone called growth hormone inhibiting hormone (GHIH) which inhibits the secretion of somatocrinin

Complete step by step answer:
Somatostatin is a polypeptide that inhibits the activity of hormones secreted by the pancreas and gastrointestinal tract. Somatostatin is widely distributed to the CNS and other tissues. The pancreas is a mixed gland present in the body which contains 3 types of cells namely: alpha cells, beta cells, delta cells. Delta cells are present in islets of Langerhans. They secrete a hormone called somatostatin to block the secretion of insulin and glucagon.
So, the correct answer is ‘Delta cella’.

Additional information:
1. Somatostatin is also called growth hormone inhibiting hormone which inhibits the release of growth
2. Hormone-releasing hormone called somatocrinin.
It is a polypeptide hormone that also inhibits numerous secondary hormones such as insulin and glucagon.
3. Delta cells present in the pyloric antrum, duodenum, and the islets of Langerhans present in the pancreas secrete somatostatin.
4. Somatostatin is also produced by neuroendocrine neurons of the hypothalamus.
5. Somatostatin is considered as an inhibitory hormone. it is induced at low pH conditions.
6. In the anterior pituitary it inhibits the release of growth hormone (GH), the release of thyroid- stimulating hormone (TSH)^, adenylyl cyclase in parietal cells, the release of prolactin (PRL).
7. In the gastrointestinal tract it suppresses the release of gastrointestinal hormones, decreases the rate of gastric emptying, and reduces smooth muscle contractions and blood flow within the intestine^, Suppresses the release of pancreatic hormones, inhibits insulin release, Inhibits the release of glucagon, the exocrine secretory action of the pancreas.

Note:
- The pancreas is called a mixed gland because it contains both exocrine parts and endocrine parts.
- Alpha cells in the pancreas secrete glucagon and beta cells produce insulin.
- Somatocrinin is also known as growth hormone- releasing hormone (GHRH)